Calcium phosphate dibasic manufacturers and suppliers

Calcium phosphate dibasic suppliers

Properties

Melting point:: 370°C(decomposition)

Density: 2.306（16℃）

RTECS: TB8528000

storage temp.: 2-8°C

solubility: Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.

form: gel (aged)

color: White

PH: 7 (10g/l, H2O, 20°C) suspension

Water Solubility: Sparingly soluble in water, practically insoluble in cold water.

Merck: 13,1697

Solubility Product Constant (Ksp): pKsp: 7

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: FUFJGUQYACFECW-UHFFFAOYSA-L

LogP: -2.148 (est)

CAS DataBase Reference: 7757-93-9(CAS DataBase Reference)

EPA Substance Registry System: Calcium hydrogen phosphate (7757-93-9)

Safety Information

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36-24/25-22

WGK Germany: 3

TSCA: Yes

HS Code: 2835 25 00

Hazardous Substances Data: 7757-93-9(Hazardous Substances Data)

Toxicity: LD50 orally in Rabbit: 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg

Use

Dibasic calcium phosphate should not be used to formulate tetracyline antibiotics. The surface of milled anhydrous dibasic calcium phosphate is alkaline and consequently it should not be used with drugs that are sensitive to alkaline pH. However, reports suggest there are differences in the surface alkalinity/acidity between the milled and unmilled grades of anhydrous dibasic calcium phosphate; the unmilled form has an acidic surface environment. This difference has important implications for drug stability, particularly when reformulating from, e.g. roller compaction to direct compression, when the particle size of the anhydrous dibasic calcium phosphate might be expected to change. Dibasic calcium phosphate dihydrate has been reported to be incompatible with a number of drugs and excipients, and many of these incompatibilities are expected to occur with dibasic calcium phosphate, anhydrous; see Calcium phosphate, dibasic dihydrate.

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