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Canagliflozin

CAS:
842133-18-0
MF:
C24H25FO5S
MW:
444.52

Properties

Boiling point:
642.9±55.0 °C(Predicted)
Density 
1.364
pka
13.34±0.70(Predicted)

Safety Information

Use

Canagliflozin is an Inhibitor drug for SGLT2. It can lower blood glucose levels by expelling the glucose from the body through the kidneys after its decomposition. In addition, Canagliflozin has a broad prospect due to its significant antiobesity effects and few hypoglycemic events. According to the results of 2 phase III clinical trials on June 9th, 2012, Canagliflozin, which is an Experimental type 2 diabetes drug of JNJ is better than Januvia of Merck or an older drug called glimepiride. Meanwhile, Canagliflozin has a more significant antiobesity effect. Compared with glimepiride, it causes less hypoglycemic events. On January 11th, 2013, Janssen Pharmaceutical of JNJ announced that its diabetes drug canagliflozin (trade name INVOKANA?)was recommended and approved by the committee of experts of FDA by the vote of 10 to 5 to treat adult patients with type 2 diabetes. On march 29th, 2013, canagliflozin (trade name INVOKANA, Janssen Pharmaceutical China of JNJ)was approved by the US Food and Drug Administration (FDA) to control blood glucose of adult patients with type 2 diabetes. On December 25th, 2013, Janssen Pharmaceutical of JNJ announced that new diabetes drug INVOKANA(canagliflozin)was approved by European Commission(EC)to treat adult patients with type 2 diabetes and improve glucose control. In September, 2014, Canagliflozin Won the positive Suggestions for recommend approval of Committee for Medicinal Products for Human Use (CHMP) of European Medicines Agency (EMA). In addition, Canagliflozin has been approved by FDA in March this year, and approved by Australia rencently. Canagliflozin is a once daily oral diabetes drug, which works by inhibiting sodium glucose co-transporter 2 (SGLT2)as a new drug. It can lower blood glucose levels by interdicting the blood glucose reabsorption of the kidneys and increasing the excretion of blood glucose in urine. Compared with non-diabetic population, the kidneys of adult patients with type 2 diabetes absorb a large number of glucose into the blood stream, which will push up the blood glucose levels. Canagliflozin is one of the most promising drug candidates of JNJ. The department of Janssen Pharmaceutical of JNJ has the rights to sell this drug in North America, South America, Europe, Middle East, Africa, Australia, New Zealand and some Asian countries.

292 supplier list of "Canagliflozin"

  • Product Name:Canagliflozin
  • Products Intro:Purity: 0.99 | Package: 0.01kg/as customer's requirment
  • Company Type: Trader
  • Country/Region: CHINA

    $0.00/ 25Kg/Bag

  • Product Name:Canagliflozin
  • Products Intro:Purity: 99% up, High Density|Package: 25Kg/Bag;0.00USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: polypeptides,Prostaglandins series

    $0.00/ 25KG

  • Product Name:Canagliflozin
  • Products Intro:Purity: 99%|Package: 25KG;0USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Paxlovid,Elagolix Sodium,Vericiguat,Venetoclax(ABT-199),Upadacitinib
  • Product Name:canagliflozin
  • Products Intro:Purity: 99 | Package: 25KG;USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Molnupiravir,Dapagliflozin,Canagliflozin,Empagliflozin,Intermediates
  • Product Name:Canagliflozin
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Canagliflozin
  • Products Intro:Package: as customers' requirement
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Canagliflozin
  • Products Intro:Purity: 99% | Package: 100g;500g;1kg;25kg...
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Canagliflozin
  • Products Intro:Purity: 0.99 | Package: 5MG;10MG;50MG;100MG,1G,5G
  • Company Type: Reagent
  • Country/Region: CHINA
  • Product Name:Canagliflozin
  • Products Intro:Purity: 99% | Package: 10g;100g;1kg; 25kg or More
  • Company Type: Manufacturer
  • Country/Region: CHINA
  • Product Name:Canagliflozin
  • Products Intro:Purity: 98.00% | Package: 1kg,10kg,50kg,100kg
  • Company Type: Trader
  • Country/Region: CHINA

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