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Eptifibatide

CAS:
148031-34-9
MF:
C35H49N11O9S2
MW:
831.96

Properties

Safety Information

Use

Eptifibatide is a cyclic heptapeptide, by preventing fibrinogen, von Willebrand factor and other adhesive ligands binding to GPIIb/IIIa , it can reversibly inhibit platelet aggregation. When administrated intravenously, vitro inhibition of platelet aggregation of eptifibatide is in a dose-and concentration-dependent manner. Inhibition of platelet aggregation is reversible after Eptifibatide infusion is stopped , which is believed to be caused by dissociation of eptifibatide and platelet. Platelet membrane glycoprotein (GP) Ⅱb/Ⅲa receptor antagonists: after platelet activation, platelet membrane GP Ⅱb/Ⅲa receptor changes its conformation to bind to the end of fibrinogen dimer to complete platelet aggregation. So, GP Ⅱb/Ⅲa receptor is believed to be the final common pathway of platelet aggregation. platelet GP Ⅱb/Ⅲa receptor antagonist Currently in clinical use, it has the following three types; ① abciximab (Abciximab reopro) is the Fab fragment of a monoclonal antibody of platelet GP Ⅱb/Ⅲa receptor. ②Eptifibatide, Integrilin is a cyclic heptapeptide. ③ tirofiban is a small molecule non-peptide compound. Eptifibatide for injection is a small molecule with heptapeptide containing Lys-Gly-Asp amino acid sequence (KGD), which is like fibrinogen recognizing and binding site GPⅡb/Ⅲa receptors ,it can highly and specially bind to platelets GPⅡb/Ⅲa receptors, it is the GPⅡb/Ⅲa receptor specific competitive inhibitor ,with a low affinity, high dissociation rate, short plasma half-life , platelet aggregation restores baseline levels within 4-8 hours after stopping the infusion . American College of Cardiology (ACC) and the American Heart Association (AHA) guidelines recommend eptifibatide injection can be used for acute coronary syndrome (unstable angina, non-ST-segment elevation myocardial infarction) or supporting through percutaneous coronary intervention (PCI) drug treatment , it is continuous used for 72 hours. Long-term animal studies on the carcinogenic potential of eptifibatide are not made. the Ames test, mouse lymphoma cells (L 5178Y, TK +/-) forward mutation test, the human lymphocyte chromosome aberration assay, or mouse micronucleus test, have shown that eptifibatide is not genotoxic. continuous infusion for a daily dose of the Eptifibatide reaching 72 mg/kg/day (calculated according to body surface area, it is 4 times of the maximum recommended human daily dose), has no effect on fertility and reproductive capacity of male and female rats. The above information is edited by the Chemicalbook of Tian Ye.

123 supplier list of "Eptifibatide"

  • Product Name:Eptifibatide Acetate
  • Products Intro:Purity: 98.0% min
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-551-65326643
  • Main Products: custom peptide,cosmetic peptide,generic peptide,peptide synthesis
  • Product Name:Eptifibatide Acetate
  • Products Intro:Purity: 98% | Package: 1gram/bottle;10g/bottle;100g/bottle;1kg/foilbag
  • Type of Enterprise: Contractor
  • Country/Region: CHINA
  • TEL: 13237129059
  • Product Name:Eptifibatide Acetate
  • Products Intro:Purity: 99% | Package: 25mg; 50mg;250mg;Bulk
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-411-39042497
  • Product Name:148031-34-9
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693

    US $3.00/ 3KG

  • Product Name:Eptifibatide
  • Products Intro:Purity: 99% | Package: 3KG;3USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-86658258
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Products Intro:Purity: 99% | Package: 5KG;1KG;25KG PRICE quotation | CustNote: Factory stock, quality assurance, price concessions
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 86-21-51086038
  • Product Name:Eptifibatide
  • Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: C35H49N11O9S2
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 86-18871470254
  • Main Products: Apis
  • Product Name:Eptifibatide
  • Products Intro:Purity: 99% HPLC | Package: 1g;10g;20g;50g;100g;200g;500g;1kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-182-6772-3597
  • Product Name:Eptifibatide
  • Products Intro:Purity: 0.99 | Package: 1KG;5KG;10KG;25KG;50KG;100KG;
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +8613111626072
  • Main Products: Food Additives,Chemical pesticides
  • Product Name:Eptifibatide Acetate
  • Products Intro:Purity: 0.99 | Package: 1kg; 25kg; or larger package as required | CustNote: pharmaceutical intermediates;Chemical Intermediate
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 021-31300828
  • Main Products: Specialty chemicals,OLED materials,Custom synthesis service

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