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Ibrutinib

CAS:
936563-96-1
MF:
C25H24N6O2
MW:
440.5

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Properties

Boiling point:
715.0±60.0 °C(Predicted)
Density 
1.34
pka
4.09±0.30(Predicted)

Safety Information

Use

Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to cure and easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions. Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit tumor cell proliferation and survival effectively. Ibrutinib could be rapidly absorbed after oral administration, during 1~2h reach maximum blood concentration, adverse reactions belong to one or two, therefore, Ibrutinib will become a new choice of treatment of CLL and MCL. Food and Drug Administration (FDA) of USA has speed up approval of Pharmacyclics Corporation and Johnson & Johnson's Imbruvica (generic name: Ibrutinib) came to market to the cure a kind of rarely aggressive leukemia-mantle cell lymphoma (MCL) in 13th November, 2013. Ibrutinib is a new kind of oral Bruton tyrosine kinase (BTK) inhibitor, it was awarded by FDA be a breakthrough drugs in February of 2013, and approved the MCL and CLL treatments in 13th November, 2013 and 12th February, 2014 respectively. It could covalently bound selectively with cysteine residues (Cys-481) in active site of Btk target protein, irreversible inhibit BTK, thereby effectively prevent tumor cells from migrating from B cell to lymphoid tissue where adapt for tumor growth. Information was collated by Xiaonan editor of Chemicalbook.

226 supplier list of "Ibrutinib"

  • Product Name:Ibrutinib
  • Products Intro:Purity: 98% | Package: 100G;1KG;5KG;10KG;25KG;50KG;100KG
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-10-60279497 +86(0)15646567669

    US $0-0 / 1g

  • Product Name:Ibrutinib
  • Products Intro:Purity: 99%+|Package: 1g;0USD|1KG;0USD|10KG;0USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-182-6772-3597
  • Product Name:PCI-32765
  • Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-571-85586718
  • Product Name:Ibrutinib
  • Products Intro:Purity: 99.00% | Package: 100g,500g,1KG,10KG,100KG
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-55531817
  • Main Products: Speciality Chemicals
  • Product Name:Ibrutinib
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693
  • Products Intro:Purity: 98% | Package: g-Kg | CustNote: White powder
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 025-83697070;product@chemlin.com.cn
  • Product Name:Ibrutinib
  • Products Intro:Purity: 99% | Package: 100g;500g;1kg;25kg...
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-21-33585366 E-mail:sales03@shyrchem.com

    US $1000.00/ 1KG

  • Product Name:Ibrutinib
  • Products Intro:Purity: 99.5% | Package: 1KG;1000USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +8615102730682; +8618874586545
  • Product Name:Ibrutinib
  • Products Intro:Purity: 98% HPLC | Package: 5MG;10MG;50MG;100MG,1G,5G
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86 21 5161 9050/ 5187 7795

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