Itraconazole manufacturers and suppliers

Itraconazole suppliers

Properties

Melting point:: 166°C

alpha: -0.1～+0.1°(D/20℃)(c=10,CH2Cl2)

Boiling point:: 850.0±75.0 °C(Predicted)

Density: 1.27 g/cm3

Flash point:: >110°(230°F)

storage temp.: 2-8°C

solubility: chloroform: 50 mg/mL, clear, colorless

form: White powder

pka: 3.7(at 25℃)

color: white

Water Solubility: Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol

Merck: 14,5245

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: VHVPQPYKVGDNFY-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes: Xi,Xn,T,F

Risk Statements: 36/37/38-36/38-22-39/23/24/25-23/24/25-11

Safety Statements: 22-26-36-45-36/37-16

RIDADR: UN 3286 8(6.1)(3) / PGII

WGK Germany: 3

RTECS: XZ5481000

HS Code: 2934990002

Toxicity: LD50 (14 day) in mice, rats, dogs (mg/kg): >320, >320, >200 orally (Van Cauteren)

Use

The imidazole antifungal agents for the triazole ring, through inhibiting the activation of cytochrome P-450, including oxidase and peroxidase, disable the 14, α-methyl sterols to be dehydrogenated and be converted to ergosterol, so that the growth and proliferation of fungi are inhibited. They have strong lipophilicity and penetrate through the biofilm to inhibit the binding of the membrane to the fungus. The antibacterial spectrum is similar to ketoconazole. It is effective in the treatment of superficial fungal diseases such as vaginal and oral candidiasis as well as skin mycosis. Furthermore, it is expected to become the highly-efficient and safe drugs for the treatment of deep fungal infections such as cryptococcal encephalitis (AIDS). It is used for the treatment of vulvovaginal candidiasis, pityriasis and skin fungal disease pityriasis caused by sensitive fungi.

You can find Itraconazole suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.