LY2109761 suppliers
LY2109761
- CAS:
- 700874-71-1
- MF:
- C26H27N5O2
- MW:
- 441.52
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 640.9±55.0 °C(Predicted)
- Density
- 1.34
- storage temp.
- Store at -20°C
- solubility
- ≥22.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 6.27±0.10(Predicted)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
- HS Code
- 29349990
Use
LY2109761 treatment induces a dose-dependent low-anchorage growth inhibition of L3.6pl/GLT cells, leading to ~33% or 73% inhibition at 2 μM and 20 μM, respectively, which can be strongly enhanced when combined with gemcitabine in combination index value of 0.36581. Blocking TβRI/II kinase activity with LY2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation. LY2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression. LY2109761 pretreatment enhances radiosensitivity of glioblastoma cells via TGF-β signaling blockage. LY2109761 (10 μM) reduces the self-renewal and proliferation of GBM-derived cancer stem–like cells (CSLC), which can be significantly enhanced when combined with radiation.
97 supplier list of "LY2109761"
- Product Name:LY2109761
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:LY2109761
- Products Intro:Purity: >98% | Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for LY2109761.
- Company Type: Trader
- Country/Region: UNITED STATES
$7.00/ 1KG
- Product Name:LY2109761
- Products Intro:Purity: 99% | Package: 1KG;7USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:LY2109761
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:LY2109761 LY-2109761
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: LY2109761
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:LY2109761
- Products Intro:Purity: 98% | Package: 100mg;1g;500g | CustNote: Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediates,raw materials,small molecule inhibitors,food additives,Biochemical reagents
- Product Name:LY2109761
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Fine Chemical,API,Raw Material,Pharmaceutical Compounds,Others
- Product Name:LY 2109761
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate
- Product Name:LY2109761
- Products Intro:Purity: >=99% | Package: $78.9/5mg;$137.9/10mg;$424.9/50mg;Bulk package | CustNote: 99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
-
2mg$39.005mg$64.001mL*10mM(inDMSO)$70.0010mg$113.0025mg$198.0050mg$353.00100mg$533.00200mg$769.00
- Product Name:LY2109761
- Products Intro:Brand:TargetMol | Product Number:T2123 | Purity:99.83%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits