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Letrozole

CAS:
112809-51-5
MF:
C17H11N5
MW:
285.30274

Properties

Melting point:
181-183°C
Boiling point:
563.5±60.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO: >50mg/mL
pka
1.52±0.11(Predicted)
form 
White powder
color 
white to off-white
Merck 
14,5450
InChIKey
HPJKCIUCZWXJDR-UHFFFAOYSA-N

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DI4957000
HS Code 
2933997500

Use

Letrozole, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)dibenzonitrile (Femara), is used for most of thesame indications as anastrozole. It reduces concentrations ofestrogens by 75% to 95%, with maximal suppressionachieved within 2 to 3 days. Letrozole is specific for aromataseinhibition, with no additional effects on adrenal corticoidbiosynthesis. CYPs 3A4 and 2A6 are involved in themetabolism of letrozole to the major carbinol metabolite,which is inactive. The loss of the triazole ring, which is involvedin coordination of the heme iron, would explain theloss of activity. Letrozole strongly inhibits CYP2A6 invitro, with moderate inhibition of CYP2C19. The effect ofthis in vitro inhibition on the pharmacokinetics of coadministereddrugs is unknown. Tamoxifen reduces the levels ofletrozole significantly if they are used together, so combinationtreatment with these agents is not recommended.

247 supplier list of "Letrozole"

  • Product Name:Letrozole
  • Products Intro:Purity: 98.5 | Package: 10g;1USD|100g;1USD|500g;3USD|1KG;10USD|10KG;20USD
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  • Product Name:Letrozole
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  • Products Intro:Purity: 90%+ | Package: 10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com | CustNote: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
  • Type of Enterprise: Reagent
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  • Main Products: Drug Impurity
  • Product Name:Letrozole
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  • Product Name:Letrozole
  • Products Intro:Purity: 99%min | Package: 1KG;10KG;100KG;500KG;100g | CustNote: ISO certified
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  • Products Intro:Purity: 99% | Package: 1g/5g/25g
  • Type of Enterprise: Trader
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  • TEL: 18017610038

    US $15.00/ 1KG

  • Product Name: Letrozole
  • Products Intro:Purity: 99% | Package: 1KG;15USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-86658258
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Letrozole
  • Products Intro:Purity: 0.98 | Package: 500G;1KG;25KG
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 15013857715
  • Product Name:Letrozole
  • Products Intro:Purity: 98% HPLC | Package: 5g/bag;100g/bag;1kg/bag;5kg/bag;25kg/bag
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 08657186217390

Letrozole Related Search:

[1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium saltIrinotecan hydrochloride trihydrateDROMETRIZOLE TRISILOXANEAnastrozoleTrazodone hydrochlorideDrometrizoleTrazodone3,5-Bis(2-cyanoprop-2-yl)benzyl bromide3,5-Bis(2-cyanoprop-2-yl)toluene5-Methyl-1,3-benzenediacetonitrile4,4'-(1-METHYLENE) BIS-BENZONITRILE(S)-1-(4-CYANOPHENYL)ETHANAMINE4-CyanobenzylamineLetrozole5-Methyl-1H-benzotriazoleChlorodimethylphenylsilaneTolyltriazole1,2,4-Triazole
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