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MLN-8237

CAS:
1028486-01-2
MF:
C27H20ClFN4O4
MW:
518.9235032

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MLN8237 shows 200-fold higher selectivity for Aurora A than the structurally related Aurora B with an IC50 of 396.5 nM, and does not have any significant activity against 205 other kinases. [1] MLN8237 (0.5 M) treatment inhibits the phosphorylation of Aurora A in MM1.S and OPM1 cells, without affecting the Aurora B mediated histone H3 phosphorylation. MLN8237 significantly inhibits cell proliferation in multiple myeloma (MM) cell lines with IC50 values of 0.003-1.71 M. MLN8237 displays more potent anti-proliferation activity against primary MM cells and MM cell lines in the presence of BM stroma cells, as well as IL-6 and IGF-1 than against MM cells alone. MLN8237 (0.5 M) induces 2- to 6-fold increase in G2/M phase in primary MM cells and cell lines, as well as significant apoptosis and senescence, involving the up-regulation of p53, p21 and p27, as well as PARP, caspase 3, and caspase 9 cleavage. In addition, MLN8237 shows strong synergistic anti-MM effect with dexamethasone, as well as additive effect with doxorubicin and bortezomib.MLN8237 (0.5 M) treatment causes the inhibition of colony formation of FLO-1, OE19, and OE33 esophageal adenocarinoma cell lines, and induces a significant increase in the percentage of polyploid cells, and subsequently an increase in the percentage of cells in the sub-G1 phase, which can be further enhanced in combination with cisplatin (2.5 M), involving the higher induction of TAp73, PUMA, NOXA, cleaved caspase-3, and cleaved PARP as compared with a single-agent treatment.

73 supplier list of "MLN-8237"

  • Product Name:Alisertib,MLN8237
  • Products Intro:Purity: 98% HPLC | Package: 5MG;10MG;50MG;100MG,1G,5G
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86 21 5161 9050/ 5187 7795
  • Product Name:MLN-8237
  • Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86 (0)571-855 867 18

    US $1.00/ 1KG

  • Product Name:MLN-8237
  • Products Intro:Purity: 98% | Package: 1KG;1USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-86658258
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Alisertib
  • Products Intro:Purity: 98% HPLC LCMS | Package: 10G;20G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-13720134139
  • Main Products: chemical products,reagents,kinase inhibitors,API
  • Product Name:MLN-8237
  • Products Intro:Purity: 0.99 | Package: 5KG;1KG
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 86-13657291602
  • Product Name:Alisertib
  • Products Intro:Purity: 98%
  • Type of Enterprise: Trader
  • Country/Region: UNITED STATES
  • TEL: 1-631-619-7922
  • Product Name:MLN-8237
  • Products Intro:Purity: 0.98 | Package: 1kg,2kg,5kg,10kg,25kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-13650506873
  • Products Intro:Purity: 97+% | Package: 1g;10g;100g;;1kg | CustNote: Z-72801
  • Type of Enterprise: Trader
  • Country/Region: UNITED STATES
  • TEL: 8485655694
  • 1 mg$25.00
    5 mg$106.00
    10 mg$188.00
  • Product Name:MLN8237
  • Products Intro:Brand: Caymanchem | Product Number: 13602 | Purity: ≥98%
  • Type of Enterprise: Trader
  • Country/Region: UNITED STATES
  • TEL: (800) 364-9897
  • 250mg$742.00
    1g$1647.00
  • Product Name:4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido-[4,5-e]azepin-2-yl)amino)-2-methoxybenzoic acid
  • Products Intro:Brand: Matrix Scientific | Product Number: 097249 | Purity: 95+%
  • Type of Enterprise: Trader
  • Country/Region: UNITED STATES
  • TEL: 803 788-9494 All other calls

MLN-8237 Related Search:

BortezomibTrametinibBI 25366-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrileOlaparib
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