MONOCROTALINE manufacturers and suppliers

MONOCROTALINE suppliers

Properties

Melting point:: 204 °C (dec.) (lit.)

alpha: -54.8o (C=5 IN CHLOROFORM)

Boiling point:: 463.55°C (rough estimate)

Density: 1.1512 (rough estimate)

refractive index: 1.5500 (estimate)

storage temp.: 2-8°C

solubility: Soluble in DMSO (up to 50 mg/ml with warming), in Ethanol (up to 10 mg/ml with warming) or in organic solvents such as Chloroform (up to 50 mg/ml)

pka: 12.21±0.60(Predicted)

color: White

Water Solubility: 11.86g/L(temperature not stated)

Merck: 13,6274

BRN: 48732

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

InChIKey: QVCMHGGNRFRMAD-XFGHUUIASA-N

LogP: -0.370 (est)

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H351

Precautionary statements: P201-P301+P310+P330

Hazard Codes: T

Risk Statements: 25-40-35

Safety Statements: 36/37/39-45

RIDADR: UN 1544 6.1/PG 3

WGK Germany: 3

RTECS: QB3140000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29399990

Toxicity: LD50 orally in rats: 71 mg/kg (Newberne)

Use

Monocrotaline (MCT) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant. It poisons livestock and humans through the ingestion of contaminated grains and other foods. Pyrrolizidine alkaloid is activated by cytochrome P450 to the reactive pyrrole metabolite dehydromonocrotaline (MCTP) in the liver. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Monocrotaline is produced for research use. It is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension.

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