Mycophenolate mofetil manufacturers and suppliers

Mycophenolate mofetil suppliers

Properties

Melting point:: 95-96°C

Boiling point:: 637.6±55.0 °C(Predicted)

Density: 1.222±0.06 g/cm3(Predicted)

storage temp.: room temp

solubility: DMSO: ≥15mg/mL

form: powder

pka: 5.6(at 25℃)

color: white to beige

Merck: 14,6327

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

InChIKey: RTGDFNSFWBGLEC-SYZQJQIISA-N

CAS DataBase Reference: 128794-94-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Danger

Hazard statements: H302-H360D-H372-H410

Precautionary statements: P202-P260-P264-P273-P301+P312-P308+P313

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 22-24/25

RIDADR: UN 3077 9 / PGIII

WGK Germany: 3

RTECS: MP7746700

HS Code: 29349990

Hazardous Substances Data: 128794-94-5(Hazardous Substances Data)

Use

Mycophenolate mofetil was launched in 1995 in the U.S.A., its first market worldwide, for the prevention of acute kidney transplant rejection in conjunction with other immunosuppressive therapy and to treat refractory acute kidney graft rejection. With improved oral absorption and bioavailability, mycophenolate mofetil is a prodrug of mycophenolic acid (MPA), a fermentation product of several Penicillium species. MPA is a selective, reversible, non-competitive inhibitor of inosinate dehydrogenase and guanylate synthetase. It inhibits the de now pathway of purine biosynthesis. MPA was found to have more potent antiproliferative effects on T and B lymphocytes than other cell types. Compared with other immunosuppressants, mycophenolate mofetil is reportedly superior due to its unique mechanism of action and excellent safety profile for long term use. Mycophenolate mofetil is being investigated clinically in the treatment of heart and liver transplantation rejection, asthma, in preventing coronary artery restenosis, and in treating rheumatoid arthritis.

You can find Mycophenolate mofetil suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.