Nateglinide manufacturers and suppliers

Nateglinide suppliers

Properties

Melting point:: 137-141°C

alpha: D20 -9.4° (c = 1 in methanol)

Boiling point:: 527.6±39.0 °C(Predicted)

Density: 1.104±0.06 g/cm3(Predicted)

storage temp.: room temp

solubility: DMSO: >5mg/mL

form: solid

pka: 3.61±0.10(Predicted)

color: white to off-white

Merck: 14,6428

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 24/25-36

WGK Germany: 3

RTECS: SQ7318950

HS Code: 29242990

Toxicity: LD50 orally in rats: >2.0 g/kg (Hasegawa)

Use

Nateglinide is a N-acylated D-phenylalanine marketed in Japan as novel orally active insulinotropic agent for the treatment of type-2 diabetes mellitus. It belongs to the class of nonsulfonylureas and shows some structural similarity to repaglinide, the only other representative in this family. In single pancreatic beta-cells isolated from rats, Nateglinide was found to specifically block the ATP-sensitive K+ channel resulting in an increase in intracellular calcium concentration. This primary action would underlie the mechanism by which Nateglinide markedly stimulates or potentiates, depending on glucose concentrations, insulin secretion from pancreatic beta-cells. Clinical studies demonstrated a good safety profile with a low potential for hypoglycemia.

You can find Nateglinide suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.