Piroxicam manufacturers and suppliers

Piroxicam suppliers

Properties

Melting point:: 198-200°C

Density: 1.3664 (rough estimate)

refractive index: 1.6320 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9).

pka: 6.3 (2:1 dioxane-water)

color: White to Light yellow

Water Solubility: Soluble in water, ethanol, chloroform, ethyl acetate.

λmax: 358nm(H2O)(lit.)

Merck: 14,7506

BCS Class: 2

InChIKey: QYSPLQLAKJAUJT-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H373

Precautionary statements: P260-P264-P270-P301+P310-P314-P405

Hazard Codes: Xn,F,T

Risk Statements: 22-25

Safety Statements: 26-36

RIDADR: UN 2811

WGK Germany: 3

RTECS: DL0705000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29349990

Toxicity: LD50 orally in mice: 360 mg/kg (Wiseman)

Use

Piroxicam (Feldene) is the most widely used oxicam becauseof its once-daily dosing schedule. It is well absorbedafter oral administration and has a plasma half-life of 50hours, thus requiring a dose of only 20 to 30 mg oncedaily. It undergoes extensive hepatic metabolism, catalyzedby CYP2C9 to give 5-hydroxypiroxicam as its majormetabolite. Several piroxicam prodrugshave been synthesized via derivatization of the enol alcoholgroup (amipiroxicam, droxicam, and pivoxicam) to reducepiroxicam-induced GI irritation.

You can find Piroxicam suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.