Propylene carbonate manufacturers and suppliers

Propylene carbonate suppliers

Properties

Melting point:: -55 °C (lit.)

Boiling point:: 240 °C (lit.)

Density: 1.204 g/mL at 25 °C (lit.)

vapor pressure: 0.13 mm Hg ( 20 °C)

refractive index: n20/D 1.421(lit.)

Flash point:: 270 °F

storage temp.: Store below +30°C.

solubility: 240g/l

form: Liquid

pka: 3.92[at 20 ℃]

color: Clear

Specific Gravity: 1.209 (20/4℃)

Relative polarity: 6

PH: 7.0 (200g/l, H2O, 20℃)

Odor: odorless

explosive limit: 1.8-14.3%(V)

Water Solubility: 240 g/L (20 ºC)

λmax: λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01

BRN: 107913

Dielectric constant: 64.4（Ambient）

Stability:: Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water.

InChIKey: RUOJZAUFBMNUDX-UHFFFAOYSA-N

LogP: -0.41 at 20℃

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319

Precautionary statements: P264-P280-P305+P351+P338-P337+P313

Hazard Codes: Xi

Risk Statements: 36

Safety Statements: 26-37/39

WGK Germany: 1

RTECS: FF9650000

F: 3-10

Autoignition Temperature: 851 °F

TSCA: Yes

HS Code: 29209010

Toxicity: LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 20000 mg/kg

Use

Propylene carbonate is used mainly as a solvent in oral and topical pharmaceutical formulations. In topical applications, propylene carbonate has been used in combination with propylene glycol as a solvent for corticosteroids. The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene carbonate has been used as a dispensing solvent in topical preparations. Propylene carbonate has also been used in hard gelatin capsules as a nonvolatile, stabilizing, liquid carrier. For formulations with a low dosage of active drug, a uniform drug content may be obtained by dissolving the drug in propylene carbonate and then spraying this solution on to a solid carrier such as compressible sugar; the sugar may then be filled into hard gelatin capsules Propylene carbonate may additionally be used as a solvent, at room and elevated temperatures, for many cellulose-based polymers and plasticizers. Propylene carbonate is also used in cosmetics.

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