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Rapamycin

CAS:
53123-88-9
MF:
C51H79NO13
MW:
914.19

Properties

Melting point:
183-185°C
alpha 
D25 -58.2° (methanol)
Boiling point:
799.83°C (rough estimate)
Density 
1.0352 (rough estimate)
vapor pressure 
0.56 hPa ( 20 °C)
refractive index 
1.5280 (estimate)
Flash point:
87 °C
storage temp. 
-20°C
solubility 
ethanol: soluble2MM
pka
10.40±0.70(Predicted)
form 
solution
color 
colorless to yellow
Water Solubility 
Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
Sensitive 
Moisture Sensitive/Light Sensitive/Hygroscopic
Merck 
14,8114

Safety Information

Symbol(GHS) 

GHS02,GHS07
Signal word 
Danger
Hazard statements 
H227-H225-H302+H312+H332-H319
Precautionary statements 
P210e-P280a-P370+P378a-P403+P235-P501a-P210-P280-P305+P351+P338
Hazard Codes 
Xi,Xn,F
Risk Statements 
36/38-36-20/21/22-11
Safety Statements 
22-24/25-37/39-26-36/37-16
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
RTECS 
VE6250000
Autoignition Temperature
301 °C
HS Code 
29349990
Toxicity
LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)

Use

Mechanistic target of rapamycin (mTOR) is a serine/threonine-specific protein kinase in the PI3/PI4-kinase family. mTOR was named after the natural macrolide rapamycin, also known as sirolimus, which was isolated from a soil sample from Easter Island in the 1970s and later evaluated as an immunosuppressive agent. The anticancer activity of rapamycin was discovered in the 1980s, although the mechanismof action and the identification of the rapamycin target, mTOR, were not elucidated until the 1990s. Rapamycin and its macrocyclic analogues, such as temsirolimus (Torisel(R), Wyeth/Pfizer) and everolimus (Afinitor(R), Novartis), are grouped as rapalogs that constitute the first-generation mTOR inhibitors. Rapamycin was approved by the US FDA in 1999 as an immunosuppressive agent to prevent organ rejection in patients receiving kidney transplants. Although a large number of clinical studies have been performed to evaluate the anticancer activities of sirolimus in different types of cancers, such as invasive bladder cancer, breast cancer, and leukemia, most studies show limited efficacy. Outside oncological indications, sirolimus was approved by FDA for the treatment of a rare progressive lung disease lymphangioleiomyomatosis in 2015. Temsirolimus was approved for the treatment of advanced RCC. Everolimus was approved in the EU for the prevention of organ rejection in heart and kidney transplant recipients before FDA approved it in 2009 for the treatment of advanced RCC resistant to sunitinib or sorafenib and for the treatment of advanced or metastatic gastrointestinal and lung tumors in 2016. Additionally, rapamycin and rapalogs are being investigated as antiaging therapeutics or for the treatment of age-related diseases. Studies have revealed that mTOR activity can be retained under hypoxic conditions via mutations in the PI3K pathway, leading to increased translation and hypoxic gene expression and tumor progression.

482 supplier list of "Rapamycin"

  • Product Name:Rapamycin
  • Products Intro:Purity: 97% | Package: 10G 100G 1KG 25KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Rapamycin Sirolimus
  • Products Intro:Purity: 99% | Package: 1g;USD|1KG;USD|10KG;USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Sirolimus
  • Products Intro:Purity: 99.99% | Package: 1g;1USD
  • Company Type: Service provider
  • Country/Region: CHINA
  • Main Products: CAS:5413-058,CAS:13605-48-6,CAS:443998-65-0,CAS:125541-22-2,CAS:49851-31-2
  • Product Name:Sirolimus/Rapamycin
  • Products Intro:Purity: 99% HPLC | Package: 1g;1kg;10kg
  • Company Type: Trader
  • Country/Region: CHINA

    $115.00-0.00 / 1g

  • Product Name:Sirolimus;Rapamycin
  • Products Intro:Purity: 98%+|Package: 1g;115USD|10g;0USD|100g;0USD|1000g;0USD
  • Company Type: Trader
  • Country/Region: CHINA

    $3500.00/ 50g

  • Product Name:Rapamycin
  • Products Intro:Purity: 98% | Package: 50g;3500USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: API(Active Pharmaceutical Ingredient),Lab Fine Chemical,Phytochemistry,Cosmetic Raw Materials

    $60.00/ 10g

  • Product Name:Sirolimus;Rapamycin
  • Products Intro:Purity: 99%|Package: 10g;60USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Xylzine Hcl

    $15.00-10.00 / 1KG

  • Product Name:Rapamycin
  • Products Intro:Purity: 99%+ HPLC|Package: 1KG;15USD|100KG;12USD|1000KG;10USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: APIS,Pharmaceutical raw materials,Cosmetic raw materials,Industrial additives,Experimental reagent

    $100.00/ 1KG

  • Product Name:Rapamycin
  • Products Intro:Purity: 0.99|Package: 1KG;100USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Methylamine Hydrochloride,Procaine,tetracaine,5337-93-9,28578-16-7
  • Product Name:Rapamycin
  • Products Intro:Purity: 99.99% | Package: 10g、100g、1kg、25kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: SARMS,Growth hormone,Anabolic Steroids,Local anesthesia,SEX Powder

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