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ChemicalBook >> CAS DataBase List >>Rapamycin

Rapamycin suppliers

Rapamycin

CAS:
53123-88-9
MF:
C51H79NO13
MW:
914.17

Properties

Melting point:
183-185°C
Boiling point:
799.83°C (rough estimate)
alpha 
D25 -58.2° (methanol)
Density 
1.0352 (rough estimate)
vapor pressure 
0.56 hPa ( 20 °C)
refractive index 
1.5280 (estimate)
Flash point:
87 °C
storage temp. 
-20°C
solubility 
ethanol: soluble2MM
form 
solution
pka
10.40±0.70(Predicted)
color 
colorless to yellow
Water Solubility 
Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
Sensitive 
Moisture Sensitive/Light Sensitive/Hygroscopic
Merck 
14,8114
Stability:
Stable for 2 years? from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS) 
GHS hazard pictograms
GHS08
Signal word 
Warning
Hazard statements 
H351-H361fd
Precautionary statements 
P201-P202-P280-P308+P313-P405-P501
Hazard Codes 
Xi,Xn,F
Risk Statements 
36/38-36-20/21/22-11
Safety Statements 
22-24/25-37/39-26-36/37-16
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
RTECS 
VE6250000
Autoignition Temperature
301 °C
HS Code 
29349990
Toxicity
LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)

Use

Rapamycin is a triene macrolide discovered in 1974 as a metabolite of Streptomyces hygroscopicus found in a soil obtained on Rapa Nui (Easter Island). Rapamycin displayed potent and selective antifungal activity, notably against Candida albicans. Interest in the metabolite waned until the structural relationship to the potent immunosuppressant fujimycin (Antibiotic FK506) was recognised in the mid-1980s. This recognition led to the re-discovery of rapamycin as a highly selective antitumor and immunosuppressant. Rapamycin inhibits the activity of the protein, mTOR (mammalian target of rapamycin) which functions in a signalling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12). The rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signalling pathway.

598 supplier list of "Rapamycin"

Sirolimus/Rapamycin
  • Product Name:Sirolimus/Rapamycin
  • Products Intro:Purity: 99% HPLC | Package: 1g;1kg;10kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Rapamycin
  • Products Intro:Purity: 98% | Package: 5KG;1KG;500g;100g
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Parecoxib sodium,Paroxetine hydrochloride

$85.00-68.00 / 1KG

  • Product Name:Coluracetam
  • Products Intro:Purity: 99%|Package: 1KG;85.00;USD|100KG;68.00;USD|1KG;85.00;USD|100KG;68.00;USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Oestradiol 17-heptanoate,Testosterone enanthate,GS-441524,Xylazine,Melanotan II
  • Product Name:Rapamycin
  • Products Intro:Purity: 98% | Package: Gram to Kilogram Class
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Macitentan,Vortioxetine hydrobromide,Selexipag,4-(4-nitrophenyl)morpholin-3-one,polymorphism XRPD test and method validation

$540.00/ 10g

  • Product Name:Rapamycin
  • Products Intro:Purity: 99% purity,WhatsApp+86 18102676775 | Package: 10g;230USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: tetracaine,lidocaine,procaine,benzocaine,levamisole
  • Product Name:Rapamycin (Sirolimus)
  • Products Intro:Purity: >98% | CustNote: BOC Sciences also provides custom synthesis services for Rapamycin (Sirolimus).
  • Company Type: Reagent
  • Country/Region: UNITED STATES
  • Product Name:Sirolimus;Rapamycin
  • Products Intro:Purity: 98%+|Package: 1g;115USD|10g;0USD|100g;0USD|1000g;0USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: SARMS,isrib,nootropic,natural compounds,peptides

$43.00-35.00 / 10grams

  • Product Name:Rapamycin
  • Products Intro:Purity: 99% | Package: 1g;10USD|1999g;5USD|19999g;1USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Rutile,PVA,Titanium dioxide,Pharmaceutical intermediates,Cobalt oxide
  • Product Name:Rapamycin
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: (7a,17b)-7-(9-Bromononyl)-estra-1,3,5(10)-triene-3,17-diol 17-acetate,4,4,5,5,5-Pentafluoro-1-pentanol,L-proline,Sodium,4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate,Cefprozil
  • Product Name:Rapamycin
  • Products Intro:Purity: 99% | Package: >=1kilogram;110USD/kilogram|>=100kilogram;90USD/kilogram
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Tirzepatide,Semaglutide,Retatrutide,NAD+,Cagrilintide
You can find Rapamycin suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

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