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Trametinib

CAS:
871700-17-3
MF:
C26H23FIN5O4
MW:
615.39

Properties

Melting point:
300-301 °C
Density 
1.74
form 
White solid.
pka
14.76±0.70(Predicted)

Safety Information

Safety Statements 
24/25
HS Code 
29339900

Use

MEK, also known as MAPK, is a dual specificity threonine/tyrosine kinase that is a key node in the Raf–Ras–MEK signaling pathway. Small-molecule MEK inhibitors represent the largest group of type III allosteric inhibitors that do not bind to the ATP binding pocket. As of December 2016, besides the FDA-approved MEK1/2 inhibitors trametinib (Mekinist(R), GlaxoSmithKline) and cobimetinib (Cotellic(R), Roche), over 10 MEK inhibitors are currently in clinical trials. Trametinib was approved by FDA in 2013 for the treatment of patients with either B-Raf V600E or V600K mutated metastatic melanoma. Considering the fact that MEK and Raf are different kinases along the same pathway of Ras–Raf–MEK/ERK signaling cascade, combination strategies using both MEK and B-Raf inhibitors were utilized to overcome the observed progression using single-agent trametinib, which usually occurs within 7months. FDA approved the combination of trametinib and dabrafenib for the treatment of B-Raf V600E/K mutated metastatic melanoma in January 2014 and the combination of cobimetinib and vemurafenib for the same type of indication. Although significant improvement in progression-free survival was observed using MEK/B-Raf combination strategy, the incidence of some common adverse effects, such as vomiting, diarrhea, nausea, rash, and pyrexia, also increased.

202 supplier list of "Trametinib"

  • Product Name:Trametinib (GSK1120212,JTP 74057)
  • Products Intro:Purity: 99% HPLC | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Trametinib
  • Products Intro:Purity: 0.99 | Package: 500g;1kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Trametinib
  • Products Intro:Purity: 99% | Package: 100g ,1KG ,5KG 25KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Speciality Chemicals
  • Product Name:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
  • Products Intro:Purity: 99% | Package: 500G;1KG;5KG;25KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Trametinib
  • Products Intro:Purity: As coa | Package: As request | CustNote: 871700-17-3
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
  • Products Intro:Purity: 98% | Package: g-Kg | CustNote: White solid
  • Company Type: Reagent
  • Country/Region: CHINA
  • Product Name:Trametinib
  • Products Intro:Purity: 99%min | Package: 1KG;10KG;100KG;500KG;100g | CustNote: ISO certified
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Trametinib
  • Products Intro:Purity: 98% HPLC | Package: 5MG;10MG;50MG;100MG,1G,5G
  • Company Type: Reagent
  • Country/Region: CHINA
  • Product Name:Trametinib
  • Products Intro:Purity: 98% HPLC LCMS | Package: 10G;20G
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: chemical products,reagents,kinase inhibitors,API

Trametinib Related Search:

TozasertibAxitinibGSK1120212 (DMSO solvate)CabozantinibDacomitinib (PF299804)Dabrafenib Mesylate(GSK-2118436B)CrizotinibAZD-9291Vandetanib Nilotinib hydrochloride anhydrousGZD 824PalbociclibLenvatinibTofacitinibSelumetinibMK-2206 2HClPD 0325901N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
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