Trimethoprim manufacturers and suppliers

Trimethoprim suppliers

Properties

Melting point:: 199-203 °C

Boiling point:: 432.41°C (rough estimate)

Density: 1.1648 (rough estimate)

refractive index: 1.6000 (estimate)

storage temp.: 2-8°C

solubility: DMSO: soluble

form: white powder

pka: 6.6(at 25℃)

color: colorless or white

Water Solubility: <0.1 g/100 mL at 24 ºC

Merck: 14,9709

BRN: 625127

BCS Class: 2

Stability:: Stable. Incompatible with strong oxidizing agents, acids.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P501

Hazard Codes: T

Risk Statements: 25

Safety Statements: 45-24/25

RIDADR: 3249

WGK Germany: 3

RTECS: UV8225000

F: 8-10-21

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29335995

Toxicity: LD50 orally in mice: 7000 mg/kg (Yamamoto)

Use

Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is closely related to several antimalarialsbut does not have good antimalarial activity by itself; it is,however, a potent antibacterial. Originally introduced incombination with sulfamethoxazole, it is now available as asingle agent.Approved by the FDA in 1980, trimethoprim as a singleagent is used only for the treatment of uncomplicatedurinary tract infections. The argument for trimethoprim asa single agent was summarized in 1979 by Wormser andDeutsch. They point out that several studies comparingtrimethoprim with TMP–SMX for the treatment ofchronic urinary tract infections found no statistically relevantdifference between the two courses of therapy.The concern is that when used as a single agent, bacterianow susceptible to trimethoprim will rapidly developresistance. In combination with a sulfonamide, however,the bacteria will be less likely to do so. That is, they willnot survive long enough to easily develop resistance toboth drugs.

You can find Trimethoprim suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.