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Trimethoprim

CAS:
738-70-5
MF:
C14H18N4O3
MW:
290.32

Properties

Melting point:
199-203 °C
Boiling point:
432.41°C (rough estimate)
Density 
1.1648 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
white powder
pka
6.6(at 25℃)
color 
colorless or white
Water Solubility 
<0.1 g/100 mL at 24 ºC
Merck 
14,9709
BRN 
625127
Stability:
Stable. Incompatible with strong oxidizing agents, acids.

Safety Information

Hazard statements 
H227
Precautionary statements 
P210e-P280a-P370+P378a-P403+P235-P501a
Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
3249
WGK Germany 
3
RTECS 
UV8225000
8-10-21
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29335995
Toxicity
LD50 orally in mice: 7000 mg/kg (Yamamoto)

Use

Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine or 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is closely related to several antimalarialsbut does not have good antimalarial activity by itself; it is,however, a potent antibacterial. Originally introduced incombination with sulfamethoxazole, it is now available as asingle agent.Approved by the FDA in 1980, trimethoprim as a singleagent is used only for the treatment of uncomplicatedurinary tract infections. The argument for trimethoprim asa single agent was summarized in 1979 by Wormser andDeutsch. They point out that several studies comparingtrimethoprim with TMP–SMX for the treatment ofchronic urinary tract infections found no statistically relevantdifference between the two courses of therapy.The concern is that when used as a single agent, bacterianow susceptible to trimethoprim will rapidly developresistance. In combination with a sulfonamide, however,the bacteria will be less likely to do so. That is, they willnot survive long enough to easily develop resistance toboth drugs.

400 supplier list of "Trimethoprim"

  • Product Name:Trimethoprim
  • Products Intro:Purity: 90%+ | Package: 10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com | CustNote: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine.
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Drug Impurity

    $0.00/ 25Kg/Bag

  • Product Name:Trimethoprim
  • Products Intro:Purity: 99% up, High Density|Package: 25Kg/Bag;0.00USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: polypeptides,Prostaglandins series
  • Product Name:Trimethoprim
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Trimethoprim
  • Products Intro:Purity: As coa | Package: As request | CustNote: 738-70-5
  • Company Type: Trader
  • Country/Region: CHINA

    $10.00/ 1KG

  • Product Name:trimethoprim
  • Products Intro:Purity: 99% | Package: 100g/ bag, 2 kg/ bag, 25kg/ carton or as required | CustNote: white to off-white solid
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Trimethoprim
  • Products Intro:Purity: 99.9% | Package: 1KG;5USD
  • Company Type: Reagent
  • Country/Region: CHINA

    $1.00/ 1KG

  • Product Name:Trimethoprim
  • Products Intro:Purity: 98% | Package: 1KG;1USD
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Trimethoprim
  • Products Intro:Purity: 0.99 | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Daily Chemicals
  • Product Name:trimethoprim
  • Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: C14H18N4O3
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Apis

Trimethoprim Related Search:

MetronidazoleEmamectin benzoateMethyl salicylateTrimethoprimBasic Violet 1Tribenuron methylPirimiphos-methyl METSULFURON METHYLTrimethoprim impurity B3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers)Diaveridine HydrochlorideChlorodimethylphenylsilane4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide4-Amino-6-methoxypyrimidineAZINPHOS-METHYLDiaveridineSulfamonomethoxine4-Methoxyphenylacetone
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