Amantadine manufacturers and suppliers

Amantadine suppliers

Properties

Melting point:: 206-208 °C(lit.)

Boiling point:: 263.29°C (rough estimate)

Density: 0.9510 (rough estimate)

refractive index: 1.5220 (estimate)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: 1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan

form: Powder

pka: 10.1(at 25℃)

color: White to cream

Water Solubility: Soluble in organic solvents. Insoluble in water.

Merck: 14,374

BRN: 2204333

InChIKey: DKNWSYNQZKUICI-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P301+P312+P330-P302+P352-P305+P351+P338

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: YD1925000

F: 10-34

HS Code: 29213000

Toxicity: LD50 oral in rat: 900mg/kg

Use

Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.

You can find Amantadine suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.