CC-223 manufacturers and suppliers

CC-223 suppliers

CC-223

CAS:: 1228013-30-6

MF:: C21H27N5O3

MW:: 397.47

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Properties

Boiling point:: 562.9±60.0 °C(Predicted)

Density: 1.37±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: insoluble in H2O; ≥108 mg/mL in DMSO; ≥20.28 mg/mL in EtOH

form: crystalline solid

pka: 13?+-.0.29(Predicted)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

Use

CC-223 is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, demonstrating inhibition of mTORC1 (pS6RP and p4EBP1) and mTORC2 [pAKT(S473)] in cellular systems. After tumor-bearing mice was treated with CC-223 for a single oral dose. It exhibited dose-dependent tumor growth inhibition in multiple solid tumor xenografts. The observed antitumor activity of CC-223 is likely to be mediated through inhibition of both mTORC1 and mTORC2. CC-223 is currently in phase I clinical trials for its treatment of advanced solid and hematologic cancers.

You can find CC-223 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the Germany here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.