Cefuroxime manufacturers and suppliers

Cefuroxime suppliers

Properties

Melting point:: 171.5-173°C

alpha: D20 +63.7° (c = 1.0 in 0.2M pH 7 phosphate buffer)

Density: 1.76

refractive index: 1.6000 (estimate)

storage temp.: 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

pka: pKa 2.5(H2O) (Uncertain)

color: White to Off-White

Water Solubility: 145mg/L at 25℃

BCS Class: 4

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H334-H317

Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501

Hazard Codes: Xn

Risk Statements: 42/43

Safety Statements: 22-24-37-45

WGK Germany: 3

RTECS: XI0329000

Use

Cefuroxime axetil (Ceftin) is the 1-acetyoxyethyl ester ofcefuroxime. During absorption, this acid-stable, lipophilic,oral prodrug derivative of cefuroxime is hydrolyzed to cefuroximeby intestinal and/or plasma enzymes. The axetilester provides an oral bioavailability of 35% to 50% of cefuroxime,depending on conditions. Oral absorption of theester is increased by food but decreased by antacids and histamineH2-antagonists. The latter effect may be because ofspontaneous hydrolysis of the ester in the intestine becauseof the higher pH created by these drugs. Axetil is used forthe oral treatment of non–life-threatening infections causedby bacteria that are susceptible to cefuroxime. The prodrugform permits twice-a-day dosing for such infections.

You can find Cefuroxime suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.