Cephalothin sodium manufacturers and suppliers

Cephalothin sodium suppliers

Properties

Melting point:: 240°C

alpha: D +135° (c = 1.0 in water)

storage temp.: Inert atmosphere,2-8°C

solubility: H₂O: 50 mg/mL, clear, faintly yellow

color: White to Off-White

Water Solubility: 158 mg/L

Merck: 13,1994

BRN: 4120706

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H317-H334

Precautionary statements: P261-P280-P284-P304+P340-P342+P311

Hazard Codes: Xn,Xi

Risk Statements: 42/43

Safety Statements: 22-36/37

WGK Germany: 2

RTECS: XI0388300

HS Code: 29419000

Toxicity: LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto)

Use

Cephalothin sodium (Keflin) occurs as a white to off-white,crystalline powder that is practically odorless. It is freelysoluble in water and insoluble in most organic solvents.Although it has been described as a broad-spectrum antibacterialcompound, it is not in the same class as the tetracyclines.Its spectrum of activity is broader than that ofpenicillin G and more similar to that of ampicillin. Unlikeampicillin, cephalothin is resistant to penicillinase producedby S. aureus and provides an alternative to the use ofpenicillinase-resistant penicillins for the treatment of infectionscaused by such strains.Cephalothin is absorbed poorly from the GI tract andmust be administered parenterally for systemic infections. It is relatively nontoxic and acid stable. It is excreted rapidlythrough the kidneys; about 60% is lost within 6 hours of administration.Pain at the site of intramuscular injection andthrombophlebitis following intravenous injection have beenreported. Hypersensitivity reactions have been observed,and there is some evidence of cross-sensitivity in patientsnoted previously to be penicillin sensitive.

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