Esomeprazole magnesium manufacturers and suppliers

Esomeprazole magnesium suppliers

Properties

Melting point:: >169°C (dec.)

alpha: D20 -128.2° (c = 1 in methanol)

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

form: Solid

color: Off-White to Beige

BCS Class: 3

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Use

Esomeprazole magnesium,S-bis(5-rnethoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-l-yl) magnesiumtrihydrate (Nexium), is the S-enantiomer ofomeprazole. The benzimidazole PPIs contain a chiral sulfuratom that form an enantiomeric pair that is stable andinsoluble under standard conditions. The S-isomer ofomeprazole has slightly greater PPI activity, and its intrinsicclearance is approximately three times lower thanthat of R-omeprazole (15 vs. 43μL/min). The lowerclearance of S-omeprazole is related to slower metabolicclearance by the CYP2C19 isozyme. Although Romeprazoleis primarily transformed to the 5-hydroxymetabolite, the S-isomer is metabolized by O-demethylationand sulfoxidation, which contribute little to intrinsicclearance.

You can find Esomeprazole magnesium suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.