Gemfibrozil manufacturers and suppliers

Gemfibrozil suppliers

Properties

Melting point:: 61-63°C

Boiling point:: 158-159 C

Density: 1.1109 (rough estimate)

refractive index: 1.5020 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, very soluble in methylene chloride, freely soluble in anhydrous ethanol and in methanol.

form: powder

pka: 4.75±0.45(Predicted)

color: White to Off-White

Water Solubility: >0.5g/L(temperature not stated)

Merck: 14,4388

BCS Class: 2

CAS DataBase Reference: 25812-30-0(CAS DataBase Reference)

IARC: 3 (Vol. 66) 1996

EPA Substance Registry System: Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- (25812-30-0)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

Hazard Codes: Xn,Xi

Risk Statements: 22-63-62-46-36/38-21

Safety Statements: 36-53-36/37-26-25

WGK Germany: 3

RTECS: YV7120000

HazardClass: IRRITANT

HS Code: 2918992090

Hazardous Substances Data: 25812-30-0(Hazardous Substances Data)

Toxicity: LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)

Use

Gemfibrozil, 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Lopid), is a congener of clofibratethat was used first in the treatment of hyperlipoproteinemia inthe mid-1970s. Its mechanism of action and use are similar tothose of clofibrate. Gemfibrozil reduces plasma levels ofVLDL triglycerides and stimulates clearance of VLDL fromplasma. The drug has little effect on cholesterol plasma levelsbut does cause an increase of HDL.Gemfibrozil is absorbed quickly from the gut and excretedunchanged in the urine. The drug has a plasma half-life of1.5 hours, but reduction of plasma VLDL concentration takesbetween 2 and 5 days to become evident. The peak effect of its hypolipidemic action may take up to 4 weeks to becomemanifest.

You can find Gemfibrozil suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.