Isoflurane manufacturers and suppliers

Isoflurane suppliers

Properties

Melting point:: 48.5°C

Boiling point:: 48.5 °C

Density: 1.510 g/mL at 25 °C

vapor pressure: 238 mmHg ( 20 °C)

refractive index: 1.3002

Flash point:: 48-49°C

storage temp.: 2-8°C

solubility: Practically insoluble in water, miscible with ethanol and trichloroethylene.

Specific Gravity: approximate 1.50

color: Colorless to Almost colorless

Water Solubility: Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water.

Merck: 14,5175

BRN: 1852087

Stability:: Stable.

InChIKey: PIWKPBJCKXDKJR-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H336

Precautionary statements: P261-P271-P304+P340+P312-P403+P233-P405-P501

Hazard Codes: F,T,Xn

Risk Statements: 36/37/38-67-48/20

Safety Statements: 26-36/37/39-24/25

RIDADR: UN 3334

WGK Germany: 3

RTECS: KN6799000

Hazard Note: Flammable/Toxic

HS Code: 2909191800

Toxicity: An isomer of enflurane with similar anesthetic properties. Isoflurane has less effect on myocardial function, leaving the cardiovascular system normally responsive to epinephrine or hypercarbia, and it does not cause a marked increase in seizure susceptibility. It was not widely used because of reports that it caused increases in liver neoplasms in mice, but this observation has been challenged and the compound reintroduced.

Use

Isoflurane is a volatile liquid (bp＝48.5°C) with an MAC of1.15, a blood:gas partition coefficient of 1.43 and high solubilityin fat. Isoflurane is a structural isomer of enflurane. Itis a known respiratory irritant, but less so than desflurane.Approximately 0.2% of the administered drug undergoesmetabolism, the rest is exhaled unchanged. The metabolismof isoflurane yields low levels of the nephrotoxic fluoride ionas well as a potentially hepatotoxic trifluoroacetylating compound). The relatively low concentrations ofthese compounds have resulted in very low risks of hepatotoxicityand nephrotoxicity. There have been no reports ofseizures caused by isoflurane and only transient increases inheart rate have been reported.

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