Loratadine manufacturers and suppliers

Loratadine suppliers

Properties

Melting point:: 134-136°C

Boiling point:: 531.3±50.0 °C(Predicted)

Density: 1.261±0.06 g/cm3(Predicted)

RTECS: TM6129200

storage temp.: 2-8°C

solubility: DMSO: 26 mg/mL, soluble

form: powder

pka: 4.27±0.20(Predicted)

color: white

Water Solubility: It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol.

Merck: 14,5578

BCS Class: 2

Stability:: Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.

InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319-H335-H315

Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 22-24/25-36-26

RIDADR: 3077

WGK Germany: 2

HS Code: 29333990

Use

Loratadine, 4-(8-chloro-5,6-dihydro-11Hbenzo[5,6]-cyclohepta[1,2-b]pyridin-l 1-ylidene-1-carboxylic acid ethyl ester, is a white to off-white powder insoluble in water but very soluble in acetone, alcohols, and chloroform. Loratadine is structurally related to the antihistamines azatadine and cyproheptadine, and to some tricyclic antidepressants. It differs from azatadine, in that a neutral carbamate group has replaced the basic tertiary amino moiety, and a phenyl ring has been substituted with a chlorine atom. Loratadine is a selective peripheral H1-antihistamine with a receptor-binding profile like that of the other members of this series, except that it has more antiserotonergic activity. Thus, it produces no substantial CNS or autonomic side effects or cardiac toxicity. Loratadine displays potency comparable with that of astemizole and greater than that of terfenadine. Loratadine is indicated for the relief of nasal and nonnasal symptoms of seasonal allergic rhinitis. In the presence of a CYP3A4 inhibitor ketoconazole, loratadine is metabolized to descarboethoxyloratadine predominantly by CYP2D6.

You can find Loratadine suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.