Methotrexate suppliers
Methotrexate
- CAS:
- 59-05-2
- MF:
- C20H22N8O5
- MW:
- 454.44
Certification
- GMP
- DMF
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Company Type
Properties
- Melting point:
- 195°C
- Boiling point:
- 561.26°C (rough estimate)
- alpha
- +17~+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
- Density
- 1.4080 (rough estimate)
- refractive index
- 1.6910 (estimate)
- Flash point:
- 11℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O: insoluble
- form
- powder
- pka
- pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
- color
- Light yellow to yellow
- biological source
- synthetic
- optical activity
- Consistent with structure
- Water Solubility
- Insoluble. <0.1 g/100 mL at 19 ºC
- Sensitive
- Light Sensitive & Hygroscopic
- Merck
- 14,5985
- BRN
- 70669
- BCS Class
- 3
- Stability:
- Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- FBOZXECLQNJBKD-ZDUSSCGKSA-N
- SMILES
- CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
- CAS DataBase Reference
- 59-05-2(CAS DataBase Reference)
- IARC
- 3 (Vol. 26, Sup 7) 1987
- NIST Chemistry Reference
- Methotrexate(59-05-2)
- EPA Substance Registry System
- Methotrexate (59-05-2)
Safety Information
- Symbol(GHS)
GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H301-H315-H319-H341-H360D
- Precautionary statements
- P201-P301+P310+P330-P302+P352-P305+P351+P338
- target organs
- Liver,Bone marrow
- Hazard Codes
- T,F
- Risk Statements
- 61-25-36/38-46-39/23/24/25-23/24/25-11
- Safety Statements
- 53-26-36/37-45-36/37/39-36-16
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- MA1225000
- F
- 3-8-10
- TSCA
- TSCA listed
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29335995
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 Oral
Muta. 2
Repr. 1B
STOT RE 1
- Hazardous Substances Data
- 59-05-2(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 135mg/kg
Use
The drug is available in 50-, 100-, 200-, and 1,000-mg vialsfor IV use. Methotrexate is used to treat several cancer typesincluding breast cancer, bladder cancer, colorectal cancer,and head and neck cancer. The mechanism of action ofmethotrexate involves inhibition of DHFR leading to a depletionof critical reduced folates. The reduced folates arenecessary for biosynthesis of several purines and pyrimidines.Resistance to methotrexate can occur because ofdecreased carrier-mediated transport of drug into cells orincreased expression of the target enzyme DHFR. Oralbioavailability varies with dose because of saturable uptakeprocesses, and high doses are required to reach therapeuticlevels in the CNS. The majority of drug dosage is excretedunchanged in the urine. The renal excretion of methotrexateis inhibited by several carboxylic acid drugs such as penicillins,probenecid, nonsteroidal anti-inflammatory agents,and aspirin. Methotrexate enhances 5-FU antitumor effectswhen given 24 hours prior to the fluoropyrimidine.Methotrexate toxicity includes myelosuppression, mucositis,nausea, vomiting, severe headaches, renal toxicity, acutecerebral dysfunction, skin rash, and hyperpigmentation.
541 supplier list of "Methotrexate"
- Product Name:Methotrexate
- Products Intro:Purity: 99% | Package: 1KG; 5KG: 25KG:500KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 7-Ethyl-10-hydroxycamptothecin (SN-38),Calcitriol,Milrinone lactate,3,6-dichloro-4-isopropylpyridazine,Citicoline Sodium
$1.00
- Product Name:Methotrexate
- Products Intro:Purity: 99.99%|Package: 1KG;1.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2F,chemical products,manufacture,intermediate,Industrial chemicals
- Product Name:Methotrexate
- Products Intro:Purity: 98.0% - 102.0%|Package: 10g;|100g;|1000g;
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Linoleic Acid,Vitamin B12,Riboflavin,β-Nicotinamide Mononucleotide,Amoxicillin trihydrate
$10.50
- Product Name:Acriflavine
- Products Intro:Purity: 99|Package: 1KG;10.50;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: acetic acid,Ethyl oleate,Hypophosphorous acid,tetramisole,OPP
- Product Name:Methotrexate
- Products Intro:Purity: 99% | Package: 1KG;50USD|1000KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Electronic material intermediates,OLED,ppb grade Monomer,Pharmaceutical intermediates,KrF/ArF Monomer
- Product Name:Methotrexate
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Methotrexate
- Products Intro:Purity: 99.9% | Package: 1KG;5USD
- Company Type: Reagent
- Country/Region: CHINA
$7
- Product Name:Methotrexate
- Products Intro:Purity: 99%|Package: 1ASSAYS;7USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:Methotrexate USP29
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: UDDA
- Product Name:Methotrexate
- Products Intro:Purity: >98% | Package: 10 g | CustNote: Please reach out to us for more information about custom solutions.
- Company Type: Trader
- Country/Region: UNITED STATES