Mevastatin manufacturers and suppliers

Mevastatin suppliers

Properties

Melting point:: 151-153 °C

alpha: D22 +283° (c = 0.48 in acetone)

Boiling point:: 555.0±50.0 °C(Predicted)

Density: 1.13±0.1 g/cm3(Predicted)

vapor pressure: 0Pa at 25℃

storage temp.: 2-8°C

solubility: DMSO: 20 mg/mL

pka: 13.49±0.40(Predicted)

form: powder

color: white

λmax: 246nm(MeOH)(lit.)

Merck: 14,6164

BRN: 1269441

InChIKey: AJLFOPYRIVGYMJ-INTXDZFKSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Danger

Hazard statements: H315-H319-H335

Precautionary statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Hazard Codes: T+

Risk Statements: 26/27/28

Safety Statements: 22-24/25-45-36/37/39

WGK Germany: 3

RTECS: EK7907100

F: 1-8-10

HS Code: 29322090

Use

Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prototype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).

You can find Mevastatin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.