Naloxone manufacturers and suppliers

Naloxone suppliers

Naloxone

CAS:: 465-65-6

MF:: C19H21NO4

MW:: 327.37

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Properties

Melting point:: 184° (Lewenstein), 177-178° (Sankyo Co.)

alpha: D20 -194.5° (c = 0.93 in CHCl3)

Boiling point:: 465.27°C (rough estimate)

Density: 1.2223 (rough estimate)

refractive index: 1.5000 (estimate)

Flash point:: 9℃

storage temp.: 2-8°C

solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly),

form: Solid

pka: pKa 7.94/7.82(H2O,t =20/37,I<0.01) (Uncertain)

color: White to Off-White

InChIKey: UZHSEJADLWPNLE-GRGSLBFTSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P501

Hazard Codes: F,T

Risk Statements: 11-23/24/25-39/23/24/25

Safety Statements: 7-16-36/37-45

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 3

HS Code: 2939190000

Toxicity: An opiate antagonist devoid of agonist activity except for mild, specific effects at very high doses. Naloxone displays a high affinity for the μ-opioid receptor, a lesser affinity for the kopioid receptor and has some affinity for δ-opioid receptor subtypes. Naloxone produces a rapid and profound reversal of the effects of opioid administration (e.g., 1 mg, i.v., blocks the effects of 25 mg of heroin). Naloxone also antagonizes the analgesia induced by placebo, acupuncture, and stress, and in animals the hypotension due to hypovolemia or spinal cord injury. Naloxone has a short half-life (about 1 h in plasma) and is not administered orally because of rapid, “first-pass” metabolism.

Use

Naloxone (Narcan) is a pure antagonist at allopioid receptor subtypes. Structurally, it resembles oxymorphoneexcept that the methyl group on the nitrogen isreplaced by an allyl group. This minor structural change retains high binding affinity to the receptor, but no intrinsicactivity. It is used to reverse the respiratory depressant effectsof opioid overdoses.Naloxone is administered intravenously with an onset ofaction within 2 minutes. Because it is competing with theopioid for the receptor sites, the dose and frequency of administrationwill depend on the amount and type of narcoticbeing antagonized. Overdoses of long-acting opioids(methadone) may require multiple IV doses of naloxone orcontinuous infusions. Neonates born to opioid-exposedmothers may be given IV naloxone at birth to reverse the effectsof opiates.Very few metabolism studies on naloxone have beenconducted, although the major metabolite found in the urineis naloxone-3-glucuronide.

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