O-Desmethylvenlafaxine manufacturers and suppliers

O-Desmethylvenlafaxine suppliers

Properties

Melting point:: 208-213°C

Boiling point:: 403.8±25.0 °C(Predicted)

Density: 1.115±0.06 g/cm3(Predicted)

Flash point:: 9℃

storage temp.: 2-8°C

solubility: insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH

pka: 10.04±0.26(Predicted)

InChIKey: KYYIDSXMWOZKMP-UHFFFAOYSA-N

LogP: 0.33 at 25℃ and pH6

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319

Precautionary statements: P305+P351+P338

Hazard Codes: F,T,Xi

Risk Statements: 11-23/24/25-39/23/24/25-36

Safety Statements: 7-16-36/37-45-26

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 3

RTECS: GV8872620

HS Code: 29225090

Use

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

You can find O-Desmethylvenlafaxine suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.