Pentobarbital suppliers

Melting point:

129.5°C

Boiling point:

367.89°C (rough estimate)

Density 

1.1376 (rough estimate)

refractive index 

1.4620 (estimate)

Flash point:

9℃

storage temp. 

2-8°C

solubility 

Very slightly soluble in water, freely soluble in ethanol. It forms water-soluble compounds with alkali hydroxides and carbonates and with ammonia.

form 

A neat solid

pka

pK1:8.11(0) (25°C)

Water Solubility 

679 mg/L

Symbol(GHS) 

GHS06,GHS08

Signal word 

Danger

Hazard statements 

H301-H336-H361d

Precautionary statements 

P201-P202-P261-P264-P270-P301+P310

Hazard Codes 

T,F

Risk Statements 

25-63-39/23/24/25-36/38-23/24/25-11

Safety Statements 

7-16-36/37-45-36/37/39-22

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

CQ5775000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2933530000

Toxicity

A barbiturate that causes CNS depression, apparently due to a facilitation of GABA-ergic inhibition. It appears that the site of action of pentobarbital may be the macromolecular complex made up of a GABA receptor, chloride channel, benzodiazepine-binding site, and picrotoxin-binding site. Barbiturates have been shown to compete for dihydropicrotoxinin-binding sites. In clinical use, barbiturates such as pentobarbital have been largely replaced as sedative-hypnotics by the much safer benzodiazepines. The sedative-hypnotic properties of barbiturates may lead to abuse, as tolerance and dependence are known to occur. In animals, pentobarbital is routinely used for its anesthetic and anticonvulsant properties, as well as for euthanasia. Pentobarbital, like other barbiturates, can induce the metabolism of other compounds by altering cytochrome P450 activity. The oral LD50 in rats is 118 mg/kg.