Podophyllotoxin manufacturers and suppliers

Podophyllotoxin suppliers

Properties

Melting point:: 183-184 °C (lit.)

alpha: -110.7 º (c=1, CHCl3)

Boiling point:: 453.31°C (rough estimate)

Density: 1.2649 (rough estimate)

refractive index: 1.4480 (estimate)

storage temp.: 2-8°C

solubility: DMSO:15.0(Max Conc. mg/mL);36.2(Max Conc. mM)

pka: 13.26±0.40(Predicted)

form: Powder

color: White to off-white

optical activity: [α]/D 131±2°, c = 1 in chloroform

Merck: 13,7628

BRN: 99163

Stability:: Very Hygroscopic

InChIKey: YJGVMLPVUAXIQN-XVVDYKMHSA-N

LogP: 2.010

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301+H311+H331-H315-H319-H335

Precautionary statements: P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338

Hazard Codes: T

Risk Statements: 21-25-36/37/38-23/25-23/24/25

Safety Statements: 36/37/39-45-26

RIDADR: UN 3462 6.1/PG 2

WGK Germany: 3

RTECS: LV2500000

F: 1-8-10

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29189090

Toxicity: LD50 in rats (mg/kg): 8.7 i.v.; 15 i.p. (Phillips)

Use

Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It binds to topoisomerase II during the late S and early G2 stage, blocking tubulin polymerization and, thus, inhibiting mitosis. In addition to being used as a cathartic, purgative, antiviral agent, vesicant, and antihelminthic, podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide , teniposide , and etopophos.

You can find Podophyllotoxin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.