Procainamide hydrochloride manufacturers and suppliers

Procainamide hydrochloride suppliers

Properties

Melting point:: 165-168 °C

Density: 1.2027 (rough estimate)

refractive index: 1.6330 (estimate)

storage temp.: 2-8°C

solubility: H2O: soluble1g/10 mL, clear, greenish-yellow

form: Powder

color: White to slightly yellow

Water Solubility: soluble

Sensitive: Light Sensitive/Air Sensitive

Merck: 13,7845

BRN: 3729517

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26-36-37/39

WGK Germany: 3

RTECS: CV2295000

HS Code: 29242990

Use

Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% recoveredas NAPA.28,29 Unlike quinidine, procainamide hydrochlorideis bound only minimally to plasma proteins.Between 75% and 95% of the drug is absorbed from the gastrointestinaltract. Plasma levels appear 20 to 30 minutesafter administration and peak in about 1 hour.30Procainamide hydrochloride appears to have all of theelectrophysiological effects of quinidine. It diminishesautomaticity, decreases conduction velocity, and increasesaction potential duration and, thereby, the refractory periodof myocardial tissue. Clinicians have favored the use of procainamidehydrochloride for ventricular tachycardias andquinidine for atrial arrhythmias, even though the two drugsare effective in either type of disorder.

You can find Procainamide hydrochloride suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.