(S)-(+)-Ibuprofen manufacturers and suppliers

(S)-(+)-Ibuprofen suppliers

Properties

Melting point:: 49-53 °C(lit.)

alpha: 57 º (c=2, EtOH)

Boiling point:: 285.14°C (rough estimate)

Density: 1.0364 (rough estimate)

refractive index: 59 ° (C=2, EtOH)

Flash point:: >230 °F

storage temp.: Sealed in dry,Room Temperature

solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL

form: solid

pka: 4.41±0.10(Predicted)

color: white

optical activity: [α]20/D +59°, c = 2 in ethanol

Water Solubility: insoluble

BRN: 3590022

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: HEFNNWSXXWATRW-JTQLQIEISA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319

Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes: Xn

Risk Statements: 63-22

Safety Statements: 45-36/37

WGK Germany: 3

HS Code: 29163990

Use

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.

You can find (S)-(+)-Ibuprofen suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.