Salinomycin manufacturers and suppliers

Salinomycin suppliers

Properties

Melting point:: 112.5-113.5 °C(lit.)

Boiling point:: 839.2±65.0 °C(Predicted)

alpha: D25 -63° (c = 1 in ethanol)

Density: 1.18±0.1 g/cm3(Predicted)

Flash point:: >110°(230°F)

storage temp.: Sealed in dry,2-8°C

solubility: insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO

pka: 6.4 (DMF)

form: White solid

color: White to light yellow

biological source: Streptomyces albus

optical activity: -6325 (cl, ethanol)

Water Solubility: Soluble in methanol. Insoluble in water

Merck: 13,8415

Stability:: Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.

InChIKey: KQXDHUJYNAXLNZ-XQSDOZFQSA-N

LogP: 5.596 (est)

CAS DataBase Reference: 53003-10-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P264-P270-P301+P310-P405-P501

PPE: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes: T,Xi

Risk Statements: 25-36/37/38

Safety Statements: 45-36-26

RIDADR: UN 3462 6.1/PG 2

WGK Germany: 3

RTECS: VO8620000

F: 10

HazardClass: 6.1(a)

PackingGroup: II

Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications: Acute Tox. 2 Oral

Hazardous Substances Data: 53003-10-4(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)

Use

Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.

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