Sorbitol manufacturers and suppliers

Sorbitol suppliers

Properties

Melting point:: 98-100 °C (lit.)

alpha: 4 º (per eur. pharm.)

Boiling point:: bp760 105°

Density: 1.28 g/mL at 25 °C

bulk density: 450kg/m3

vapor density: <1 (vs air)

vapor pressure: <0.1 mm Hg ( 25 °C)

refractive index: n20/D 1.46

FEMA: 3029 | D-SORBITOL

Flash point:: >100°C

storage temp.: room temp

solubility: Very soluble in water, slightly soluble in ethanol

form: liquid

pka: pKa (17.5°): 13.6

color: White

Specific Gravity: 1.28

Odor: Odorless

PH Range: 5 - 7 at 182 g/l at 25 °C

PH: 5.0-7.0 (25℃, 1M in H2O)

Odor Type: caramellic

optical activity: [α]20/D 1.5±0.3°, c = 10% in H2O

Water Solubility: SOLUBLE

Sensitive: Hygroscopic

λmax: λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.045

Merck: 14,8725

BRN: 1721899

Henry's Law Constant: 6.6×10¹⁴ mol/(m³Pa) at 25℃, Compernolle and Müller (2014)

Dielectric constant: 33.5(27℃)

Stability:: Stable. Avoid strong oxidizing agents. Protect from moisture.

Cosmetics Ingredients Functions: PERFUMING
HUMECTANT
FRAGRANCE
SKIN CONDITIONING

InChI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

InChIKey: FBPFZTCFMRRESA-JGWLITMVSA-N

SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

LogP: -4.67

CAS DataBase Reference: 50-70-4(CAS DataBase Reference)

NIST Chemistry Reference: Sorbitol(50-70-4)

EPA Substance Registry System: Sorbitol (50-70-4)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302+H312+H332

Precautionary statements: P501-P261-P270-P271-P264-P280-P362+P364-P301+P312+P330-P302+P352+P312-P304+P340+P312

PPE: Eyeshields, Gloves, type N95 (US)

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 8-36-26-24/25

WGK Germany: 2

RTECS: LZ4290000

F: 3

Autoignition Temperature: 420 °C

TSCA: TSCA listed

HS Code: 29054491

Storage Class: 11 - Combustible Solids

Hazardous Substances Data: 50-70-4(Hazardous Substances Data)

Toxicity: LD50 orally in Rabbit: 15900 mg/kg

Use

Sorbitol is widely used as an excipient in pharmaceutical formulations. It is also used extensively in cosmetics and food products. Sorbitol is used as a diluent in tablet formulations prepared by either wet granulation or direct compression. It is particularly useful in chewable tablets owing to its pleasant, sweet taste and cooling sensation. In capsule formulations it is used as a plasticizer for gelatin. Sorbitol has been used as a plasticizer in film formulations. In liquid preparations sorbitol is used as a vehicle in sugar-free formulations and as a stabilizer for drug, vitamin, and antacid suspensions. Furthermore, sorbitol is used as an excipient in liquid parenteral biologic formulations to provide effective protein stabilization in the liquid state. It has also been shown to be a suitable carrier to enhance the in vitro dissolution rate of indometacin. In syrups it is effective in preventing crystallization around the cap of bottles. Sorbitol is additionally used in injectable and topical preparations, and therapeutically as an osmotic laxative. Sorbitol may also be used analytically as a marker for assessing liver blood flow.

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