Topotecan hydrochloride manufacturers and suppliers

Topotecan hydrochloride suppliers

Properties

Melting point:: 213-218°C

storage temp.: Sealed in dry,Room Temperature

solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form: Light yellow to greenish powder.

color: White to Off-White

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H351-H340-H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501

Hazard Codes: T

Risk Statements: 25-36/37/38-46

Safety Statements: 26-36/37/39-45

HS Code: 29420000

Use

Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy. In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The Ⅲ clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome. Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors. Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.

You can find Topotecan hydrochloride suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.