Trilostane manufacturers and suppliers

Trilostane suppliers

Properties

Melting point:: 264 °C

alpha: D25 +137.4° (c = 1 in pyridine)

Boiling point:: 467.02°C (rough estimate)

Density: 1.1213 (rough estimate)

refractive index: 1.5614 (estimate)

storage temp.: 2-8°C

solubility: DMSO: ≥17mg/mL

form: powder

pka: 8.57±0.70(Predicted)

color: white to tan

InChIKey: KVJXBPDAXMEYOA-CXANFOAXSA-N

SMILES: [C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H315-H319-H361

Precautionary statements: P201-P302+P352-P305+P351+P338-P308+P313

Hazard Codes: Xi

Risk Statements: 36/37/38-62

Safety Statements: 26-36/37

WGK Germany: 3

HS Code: 29372900

Use

Trilostane, that is 4α, 5α-epoxy-2-cyano-3,17β-diol, can reversibly inhibit 3β-hydroxy steroid dehydrogenase and △5, 4-isomerase in the adrenal cortex to block the biosynthesis of mineralocorticoid and glucocorticoid. In 1980, it was approved for the treatment of hyperaldosteronism and cortisol excess disease in the United Kingdom. In 1985, it was approved for the treatment of Cushing's syndrome in the United States, which is adrenal cortex hyperactivity disorder. In view of the older animals, especially older dogs are susceptible to Cushing's syndrome. Trilostane can relieve the disease symptoms of more than 90% of dogs, and improve their quality of life. So the drug has also been granted for the treatment of animals in the United Kingdom. Trilostane itself has no hormonal activity. Its side effects is less, and its safety and tolerability are also particularly good. The above information is edited by the chemicalbook of Ge Qian.

You can find Trilostane suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.