Zolmitriptan manufacturers and suppliers

Zolmitriptan suppliers

Properties

Melting point:: 136-141°C

alpha: D22 -5.79° (c = 0.5 in methanol)

Boiling point:: 563.3±38.0 °C(Predicted)

Density: 1.217±0.06 g/cm3(Predicted)

storage temp.: 15-25°C

solubility: Soluble in DMSO at 5mg/ml

pka: 9.64(at 25℃)

form: powder

color: white to beige

optical activity: [α]/D -3 to -8°, c = 1 in methanol

λmax: 225nm(lit.)

Merck: 14,10189

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChI: 1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1

InChIKey: ULSDMUVEXKOYBU-ZDUSSCGKSA-N

SMILES: CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12

CAS DataBase Reference: 139264-17-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312+P330-P501

Hazard Codes: Xi,Xn

Risk Statements: 36/37/38-22

Safety Statements: 26-36

WGK Germany: 3

RTECS: RQ2707000

HS Code: 29349990

Storage Class: 11 - Combustible Solids

Toxicity: women,TDLo,oral,6mg/kg/43W-I (6mg/kg),BEHAVIORAL: HEADACHE,Lancet. Vol. 353, Pg. 378, 1999.

Use

Zolmitriptan, the second triptan marketed (approved in1997), has a much better bioavailability (40%–48%) thansumatriptan. It is rapidly absorbed after oral or nasal sprayadministration. It also has an orally disintegrating tablet formulation(Zomig ZMT), which can be taken without water.Zolmitriptan undergoes rapid N-demethylation via CYP1A2to a more potent, active metabolite, N-desmethylzolmitriptan,which is 2 to 6 times more potent than the parentdrug. This active metabolite was detected 5 minutesafter dosing and accounts for about two thirds of the plasmaconcentration of the administered dose of the parent drug.284Thus, it is reasonable to assume that the therapeutic effectsand especially the CNS side effects of zolmitriptan must bein part attributed to the plasma levels of this active metabolite,at least until it is further degraded by hepatic MAO-Ato its inactive indole acetic acid derivatives.

You can find Zolmitriptan suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.