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ChemicalBook >> CAS DataBase List >> N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

$30 - $7364
Product name: N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea
CAS: 1020172-07-9
MF: C30H28FN7O3
MW: 553.59
EINECS:
MDL Number:MFCD19443646
Synonyms:DCC-2036 (Rebastinib);N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(MethylcarbaMoyl)pyridin-4-yl);1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea;N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea DCC-2036 (Rebastinib);Rebastinib(DCC-2036);N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea;Rebastinib Tosylate;4-(4-(3-(3-(tert-Butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)ureido)-3-fluorophenoxy)-N-methylpic

Price63 Properties Safety Information Description

63 prices

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aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC

Package

10mM*1mLinDMSO(Solid+Solvent)
2x5mg
500mg
1000mg
10mM(in 1mL DMSO)
1.00g
10mM*1mLinDMSO(Solution)
5g
5.00g
10mM(in1mLDMSO)
1mg
5MG
10mg
25MG
50mg
100mg
200MG
250mg
1G

Manufactureraablocks
Product numberAA000692
Product descriptionN-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98
Packaging1mg
Price$44
Updated2026-05-25
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Manufactureraablocks
Product numberAA000692
Product descriptionN-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%
Packaging10mg
Price$47
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000692
Product descriptionN-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%
Packaging50mg
Price$134
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000692
Product descriptionN-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%
Packaging100mg
Price$227
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000692
Product descriptionN-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%
Packaging250mg
Price$384
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberM15887
Product descriptionDCC-2036 98%
Packaging100MG
Price$210
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberM15887
Product descriptionDCC-2036 98%
Packaging25MG
Price$90
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberM15887
Product descriptionDCC-2036 98%
Packaging5MG
Price$30
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberM15887
Product descriptionDCC-2036 98%
Packaging1G
Price$1200
Updated2026-05-27
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ManufacturerAK Scientific
Product numberX7511
Product descriptionRebastinib
Packaging1g
Price$2523
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0001381
Product descriptionREBASTINIB 95.00%
Packaging200MG
Price$2800
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB1404
Product descriptionDCC-2036 (Rebastinib)
Packaging10mM(in1mLDMSO)
Price$77
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB1404
Product descriptionDCC-2036 (Rebastinib)
Packaging5mg
Price$64
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB1404
Product descriptionDCC-2036 (Rebastinib)
Packaging10mg
Price$109
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB1404
Product descriptionDCC-2036(Rebastinib)
Packaging10mM(in 1mL DMSO)
Price$121
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB1404
Product descriptionDCC-2036 (Rebastinib)
Packaging50mg
Price$275
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000692	N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98	1mg	$44	2026-05-25	Buy
aablocks	AA000692	N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%	10mg	$47	2026-05-25	Buy
aablocks	AA000692	N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%	50mg	$134	2026-05-25	Buy
aablocks	AA000692	N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%	100mg	$227	2026-05-25	Buy
aablocks	AA000692	N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea 98%	250mg	$384	2026-05-25	Buy
ACHEMBLOCK	M15887	DCC-2036 98%	100MG	$210	2026-05-27	Buy
ACHEMBLOCK	M15887	DCC-2036 98%	25MG	$90	2026-05-27	Buy
ACHEMBLOCK	M15887	DCC-2036 98%	5MG	$30	2026-05-27	Buy
ACHEMBLOCK	M15887	DCC-2036 98%	1G	$1200	2026-05-27	Buy
AK Scientific	X7511	Rebastinib	1g	$2523	2021-12-16	Buy
American Custom Chemicals Corporation	INB0001381	REBASTINIB 95.00%	200MG	$2800	2021-12-16	Buy
ApexBio Technology	B1404	DCC-2036 (Rebastinib)	10mM(in1mLDMSO)	$77	2026-05-06	Buy
ApexBio Technology	B1404	DCC-2036 (Rebastinib)	5mg	$64	2026-05-06	Buy
ApexBio Technology	B1404	DCC-2036 (Rebastinib)	10mg	$109	2026-05-06	Buy
ApexBio Technology	B1404	DCC-2036(Rebastinib)	10mM(in 1mL DMSO)	$121	2021-12-16	Buy
ApexBio Technology	B1404	DCC-2036 (Rebastinib)	50mg	$275	2026-05-06	Buy

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Properties

Melting point :>181°C (dec.)
Boiling point :666.8±55.0 °C(Predicted)
Density :1.32
storage temp. :-20°C Freezer
solubility :Methanol (Slightly)
pka :12.25±0.70(Predicted)
form :Solid
color :Off-White

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rebastinib is an orally bioavailable tyrosine kinase inhibitor that inhibits Abl1 (IC₅₀ = 0.8 nM) as well as the gatekeeper mutant Abl1^T315I (IC₅₀ = 4 nM) and the activation loop mutant Abl1^H396P. It also inhibits the Src family kinases Src, Lyn, Fgr, and Hck and the tyrosine kinases KDR, FLT3, and Tie2 at nanomolar concentrations. Rebastinib inhibits mutant Abl1^T315I signaling and prolongs survival in a mouse Ba/F3 cell allograft model. Rebastinib also exhibits in vivo antineoplastic activity against cells with the T674I point mutation of FIP1-like-1-platelet-derived growth factor receptor α.

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Suppliers and manufacturers

Chembest Research Laboratories Limited WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. Jinan Trio PharmaTech Co., Ltd. Dalian Meilun Biotech Co., Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD Shanghai Witofly Chemical Co.,Ltd AdooQ BioScience, LLC CEG Chemical Science&Technology Co., Ltd. GIHI CHEMICALS CO.,LTD

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N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

Properties

Safety Information

Description

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