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ChemicalBook >> CAS DataBase List >> 3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide price.
  • $32 - $1900
  • Product name: 3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
  • CAS: 1336960-13-4
  • MF: C37H38BrF3N4O
  • MW: 691.62
  • EINECS:
  • MDL Number:MFCD28009510
  • Synonyms:3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide;GSK2193874;TRPV4 antagonist GS2193874;GSK 2193874; GSK2193874;4-Quinolinecarboxamide, 3-([1,4'-bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-;GSK2193874 >=98% (HPLC);GSK2193874,inhibit,GSK 2193874,Transient receptor potential channels,GSK-2193874,Inhibitor,TRP Channel;3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide
Price28 Properties Safety Information Description
28 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 5
  • 2mg
  • 25
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3286DL
  • Product description7-Bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
  • Packaging10mg
  • Price$302
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892019
  • Product descriptionGSK2193874 98+%
  • Packaging5mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892019
  • Product descriptionGSK2193874 98+%
  • Packaging10mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892019
  • Product descriptionGSK2193874 98+%
  • Packaging50mg
  • Price$143
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA892019
  • Product descriptionGSK2193874 98+%
  • Packaging100mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7751
  • Product descriptionGSK2193874
  • Packaging2mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7751
  • Product descriptionGSK2193874
  • Packaging5mg
  • Price$122
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7751
  • Product descriptionGSK2193874
  • Packaging10mg
  • Price$213
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7751
  • Product descriptionGSK2193874
  • Packaging25mg
  • Price$425
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7751
  • Product descriptionGSK2193874
  • Packaging50mg
  • Price$764
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7751
  • Product descriptionGSK2193874
  • Packaging100mg
  • Price$1370
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17715
  • Product descriptionGSK2193874 ≥95%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17715
  • Product descriptionGSK2193874 ≥95%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17715
  • Product descriptionGSK2193874 ≥95%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17715
  • Product descriptionGSK2193874 ≥95%
  • Packaging25mg
  • Price$396
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7612
  • Product descriptionGSK2193874 99.68%
  • Packaging2mg
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3286DL 7-Bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide 10mg $302 2021-12-16 Buy
Ambeed A892019 GSK2193874 98+% 5mg $38 2021-12-16 Buy
Ambeed A892019 GSK2193874 98+% 10mg $53 2021-12-16 Buy
Ambeed A892019 GSK2193874 98+% 50mg $143 2021-12-16 Buy
Ambeed A892019 GSK2193874 98+% 100mg $210 2021-12-16 Buy
ApexBio Technology B7751 GSK2193874 2mg $87 2021-12-16 Buy
ApexBio Technology B7751 GSK2193874 5mg $122 2021-12-16 Buy
ApexBio Technology B7751 GSK2193874 10mg $213 2021-12-16 Buy
ApexBio Technology B7751 GSK2193874 25mg $425 2021-12-16 Buy
ApexBio Technology B7751 GSK2193874 50mg $764 2021-12-16 Buy
ApexBio Technology B7751 GSK2193874 100mg $1370 2021-12-16 Buy
Cayman Chemical 17715 GSK2193874 ≥95% 1mg $32 2024-03-01 Buy
Cayman Chemical 17715 GSK2193874 ≥95% 5mg $100 2024-03-01 Buy
Cayman Chemical 17715 GSK2193874 ≥95% 10mg $184 2024-03-01 Buy
Cayman Chemical 17715 GSK2193874 ≥95% 25mg $396 2024-03-01 Buy
ChemScene CS-7612 GSK2193874 99.68% 2mg $60 2021-12-16 Buy
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Properties

Boiling point :737.8±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble10mg/mL, clear
pka :12.82±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GSK2193874 is a potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC50 values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively. It is selective for TRPV4 over ~200 other human receptors, channels, and enzymes. GSK2193874 is effective in vivo, as it resolves pulmonary edema resulting from myocardial infarction in mice. TRPV4 blockade with GSK2193874 does not alter heart rate or blood pressure in rats, although it attenuates decreases in pulmonary and systemic arterial pressures induced by TRPV4 agonists.

Suppliers and manufacturers

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