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ChemicalBook >> CAS DataBase List >> Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- price.
  • $17 - $3791
  • Product name: Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-
  • CAS: 217645-70-0
  • MF: C21H24ClFN4O3
  • MW: 434.89
  • EINECS:
  • MDL Number:MFCD09859709
  • Synonyms:Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-;(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-2-Methyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-urea;ZK811752 (BX471);(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine ZK811752 (BX471);N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea;BX471(ZK-811752);Piperazine,1-[[2-[(aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-;(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine
Price55 Properties Safety Information Description
55 prices
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  • aablocks
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Package
  • 10mM*1mLinDMSO
  • 1mg
  • 10mM(1mLinDMSO)
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
  • Packaging1mg
  • Price$17
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC)
  • Packaging5mg
  • Price$27
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC)
  • Packaging10mg
  • Price$48
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
  • Packaging25mg
  • Price$87
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
  • Packaging50mg
  • Price$147
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
  • Packaging100mg
  • Price$263
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
  • Packaging250mg
  • Price$441
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BEZU
  • Product description(2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98%
  • Packaging1g
  • Price$1682
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberS72364
  • Product descriptionZK-811752 98%
  • Packaging1G
  • Price$900
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberS72364
  • Product descriptionZK-811752 98%
  • Packaging100MG
  • Price$180
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product number3511AH
  • Product description1-(2-(2-((R)-4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea
  • Packaging250mg
  • Price$421
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA434794
  • Product descriptionBX 471 98+%
  • Packaging10mg
  • Price$333
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA434794
  • Product descriptionBX 471 98+%
  • Packaging5mg
  • Price$222
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA434794
  • Product descriptionBX 471 98+%
  • Packaging50mg
  • Price$735
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA434794
  • Product descriptionBX 471 98+%
  • Packaging25mg
  • Price$566
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000393
  • Product descriptionBX 471 95.00%
  • Packaging5MG
  • Price$499.94
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% 1mg $17 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC) 5mg $27 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine ≥98%(HPLC) 10mg $48 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% 25mg $87 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% 50mg $147 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% 100mg $263 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% 250mg $441 2026-05-28 Buy
aablocks AA00BEZU (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine 98% 1g $1682 2026-05-28 Buy
ACHEMBLOCK S72364 ZK-811752 98% 1G $900 2026-05-27 Buy
ACHEMBLOCK S72364 ZK-811752 98% 100MG $180 2026-05-27 Buy
AK Scientific 3511AH 1-(2-(2-((R)-4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)-5-chlorophenyl)urea 250mg $421 2021-12-16 Buy
Ambeed A434794 BX 471 98+% 10mg $333 2021-12-16 Buy
Ambeed A434794 BX 471 98+% 5mg $222 2021-12-16 Buy
Ambeed A434794 BX 471 98+% 50mg $735 2021-12-16 Buy
Ambeed A434794 BX 471 98+% 25mg $566 2021-12-16 Buy
American Custom Chemicals Corporation INB0000393 BX 471 95.00% 5MG $499.94 2021-12-16 Buy
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Properties

Boiling point :593.5±50.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ≥25mg/mL
pka :13.66±0.70(Predicted)
form :White powder
color :white to tan
InChI :1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
InChIKey :XQYASZNUFDVMFH-CQSZACIVSA-N
SMILES :N(C1=CC(Cl)=CC=C1OCC(N1CCN(CC2=CC=C(F)C=C2)C[C@H]1C)=O)C(N)=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The CC chemokine receptor-1 (CCR1), whose ligands include macrophage inflammatory protein-1α (MIP-1α), RANTES, and monocyte chemotactic protein-3 (MCP-3), has a central role in leukocyte trafficking and is highly expressed in certain autoimmune diseases. BX 471 is a nonpeptide CCR1 antagonist that has been shown to displace MIP-1α, RANTES, and MCP-3 with Ki values of 1, 2.8, and 5.5 nM, respectively. It demonstrates >10,000-fold selectivity for CCR1 over 28 additional G protein-coupled receptors, including related chemokine receptors. In a rat experimental allergic encephalomyelitis model of multiple sclerosis, BX 471 at 50 mg/kg was shown to significantly reduce the severity of the disease. BX 471 also decreases the inflammatory response during sepsis, blocks migration of monocytes isolated from rheumatoid arthritis patients, and prevents macrophage and T-cell recruitment in a mouse model of lupus nephritis.

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Lexeon Biotech (Chengdu) Co., Ltd. Shanghai Boyle Chemical Co., Ltd. Haoyuan Chemexpress Co., Ltd. TOKYO CHEMICAL INDUSTRY CO., LTD. TCI Europe TCI AMERICA AdooQ BioScience, LLC ShangHai Caerulum Pharma Discovery Co., Ltd. Bide Pharmatech Ltd. Shanghai HuanChuan Industry Co.,Ltd.