4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
![4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE price.](/CAS/GIF/39674-97-0.gif)
|
- $32 - $2700
- Product name: 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
- CAS: 39674-97-0
- MF: C14H11NO3
- MW: 241.24
- EINECS:
- MDL Number:MFCD00616487
- Synonyms:4-HYDROXY-3,3-DIMETHYL-2H-BENZ[G]INDOLE-2,5(3H)-DIONE;4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE;BVT 948;BVT-948 (SPS8I-3);2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl-;Cytochrome P450,Histone Methyltransferase,BVT 948,BVT948,Inhibitor,Phosphatase,CYPs,BVT-948,inhibit;BVT 948, Protein tyrosine phosphatase (PTP) inhibitor;BVT948, 10 mM in DMSO
27 prices
Selected condition：
Brand
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10MG
- 1MG
- 10
- 50
- 25MG
- 10mM*1mLinDMSO
- 50MG
- 100MG
- 250mg
- 1g
- ManufacturerACHEMBLOCK
- Product numberZ238274
- Product descriptionBVT948 98%
- Packaging25MG
- Price$190
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238274
- Product descriptionBVT948 98%
- Packaging100MG
- Price$425
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA545026
- Product description4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione 98%
- Packaging5mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005202
- Product descriptionBVT-948 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005202
- Product descriptionBVT-948 95.00%
- Packaging5MG
- Price$502
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005202
- Product descriptionBVT-948 95.00%
- Packaging10MG
- Price$685.21
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005202
- Product descriptionBVT-948 95.00%
- Packaging50MG
- Price$1138.78
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4543
- Product descriptionBVT 948
- Packaging5mg
- Price$117
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4543
- Product descriptionBVT948
- Packaging5mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥98%
- Packaging50mg
- Price$276
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥95%
- Packaging50mg
- Price$304
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥98%
- Packaging10mg
- Price$127
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥95%
- Packaging10mg
- Price$140
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥95%
- Packaging1mg
- Price$36
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number16615
- Product descriptionBVT 948 ≥98%
- Packaging5mg
- Price$95
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | Z238274 | BVT948 98% | 25MG | $190 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238274 | BVT948 98% | 100MG | $425 | 2026-05-27 | Buy |
| Ambeed | A545026 | 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione 98% | 5mg | $116 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005202 | BVT-948 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005202 | BVT-948 95.00% | 5MG | $502 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005202 | BVT-948 95.00% | 10MG | $685.21 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005202 | BVT-948 95.00% | 50MG | $1138.78 | 2021-12-16 | Buy |
| ApexBio Technology | A4543 | BVT 948 | 5mg | $117 | 2026-05-06 | Buy |
| ApexBio Technology | A4543 | BVT948 | 5mg | $205 | 2021-12-16 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥98% | 50mg | $276 | 2024-03-01 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥95% | 50mg | $304 | 2026-04-30 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥98% | 10mg | $127 | 2024-03-01 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥95% | 10mg | $140 | 2026-04-30 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥95% | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 16615 | BVT 948 ≥98% | 5mg | $95 | 2024-03-01 | Buy |
Properties
Boiling point :400.8±55.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: 18 mg/mL
pka :5.78±0.40(Predicted)
form :solid
color :red
InChI :InChI=1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
InChIKey :BAQXWJQSUXZVIP-UHFFFAOYSA-N
SMILES :N1=C2C(=C(O)C(=O)C3=CC=CC=C32)C(C)(C)C1=O
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: 18 mg/mL
pka :5.78±0.40(Predicted)
form :solid
color :red
InChI :InChI=1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
InChIKey :BAQXWJQSUXZVIP-UHFFFAOYSA-N
SMILES :N1=C2C(=C(O)C(=O)C3=CC=CC=C32)C(C)(C)C1=O
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
BVT 948 is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTP; IC50s = 0.09-1.7 μM). It facilitates the oxidation of the catalytic cysteine residue by hydrogen peroxide. Similarly, it inhibits redox-sensitive cytochrome P450 (CYP) isoforms, including CYP2C19 and CYP2D6, with IC50 values less than 10 μM. BVT 948 also inhibits the protein methyltransferases SETD8, SETD2, G9a, SMYD2, CARM1, and PRMT3 with IC50 values from 0.7 to 3.2 μm. Presumably through its effects on PTPs, BVT 948 enhances insulin signaling in cells and insulin tolerance in ob/ob mice, suppresses the expression of matrix metalloproteinase-9 and invasion in breast cancer cells, and increases NMDA-induced substance P release by spinal cord slices.More related product prices
Related product price
-
39674-97-0
$32-2700
