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ChemicalBook >> CAS DataBase List >> 5-Azacytidine

5-Azacytidine

5-Azacytidine price.
  • $7 - $1767.15
  • Product name: 5-Azacytidine
  • CAS: 320-67-2
  • MF: C8H12N4O5
  • MW: 244.2
  • EINECS:206-280-2
  • MDL Number:MFCD00006539
  • Synonyms:Antibiotic U 18496-15N4;Azacitidine-15N4;Azacytidine-15N4;LadakaMycin-15N4;LedakaMycin-15N4;Mylosar-15N4;NSC 102816-15N4;NSC 103-627-15N4
63 prices
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  • Abosyn
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  • Biorbyt Ltd
  • Biosynth Carbosynth
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  • 10mM(in 1mL DMSO)
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  • 1vial
  • 100G
  • ManufacturerAbosyn
  • Product number61-11867
  • Product description4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one 95-98%
  • Packaging1g
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-A0271-G001
  • Product description5-Azacytidine ≥98%(HPLC)
  • Packaging1g
  • Price$171
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10124
  • Product description5-Azacytidine
  • Packaging1g
  • Price$80
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ64159
  • Product description5-Azacytidine, 98%
  • Packaging1g
  • Price$63.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64159
  • Product description5-Azacytidine, 98%
  • Packaging5g
  • Price$245.65
  • Updated2024-03-01
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  • ManufacturerAmbeed
  • Product numberA386837
  • Product description5-Azacytidine 95+%
  • Packaging100mg
  • Price$7
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA386837
  • Product description5-Azacytidine 95+%
  • Packaging250mg
  • Price$10
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA386837
  • Product description5-Azacytidine 95+%
  • Packaging1g
  • Price$23
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA386837
  • Product description5-Azacytidine 95+%
  • Packaging5g
  • Price$90
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA386837
  • Product description5-Azacytidine 95+%
  • Packaging25g
  • Price$324
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003444
  • Product descriptionMYLOSAR 95.00%
  • Packaging5MG
  • Price$514
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003444
  • Product descriptionMYLOSAR 95.00%
  • Packaging1G
  • Price$825
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003444
  • Product descriptionMYLOSAR 95.00%
  • Packaging5G
  • Price$1767.15
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1907
  • Product description5-Azacytidine
  • Packaging250mg
  • Price$55
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA1907
  • Product description5-Azacytidine
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1907
  • Product description5-Azacytidine
  • Packaging1g
  • Price$175
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-11867 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one 95-98% 1g $75 2021-12-16 Buy
Adipogen Life Sciences CDX-A0271-G001 5-Azacytidine ≥98%(HPLC) 1g $171 2021-12-16 Buy
AK Scientific J10124 5-Azacytidine 1g $80 2021-12-16 Buy
Alfa Aesar J64159 5-Azacytidine, 98% 1g $63.65 2024-03-01 Buy
Alfa Aesar J64159 5-Azacytidine, 98% 5g $245.65 2024-03-01 Buy
Ambeed A386837 5-Azacytidine 95+% 100mg $7 2021-12-16 Buy
Ambeed A386837 5-Azacytidine 95+% 250mg $10 2021-12-16 Buy
Ambeed A386837 5-Azacytidine 95+% 1g $23 2021-12-16 Buy
Ambeed A386837 5-Azacytidine 95+% 5g $90 2021-12-16 Buy
Ambeed A386837 5-Azacytidine 95+% 25g $324 2021-12-16 Buy
American Custom Chemicals Corporation API0003444 MYLOSAR 95.00% 5MG $514 2021-12-16 Buy
American Custom Chemicals Corporation API0003444 MYLOSAR 95.00% 1G $825 2021-12-16 Buy
American Custom Chemicals Corporation API0003444 MYLOSAR 95.00% 5G $1767.15 2021-12-16 Buy
ApexBio Technology A1907 5-Azacytidine 250mg $55 2021-12-16 Buy
ApexBio Technology A1907 5-Azacytidine 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A1907 5-Azacytidine 1g $175 2021-12-16 Buy

Properties

Melting point :226-232 °C (dec.)(lit.)
alpha :40 º (C=1, H2O 22 ºC)
Boiling point :387.12°C (rough estimate)
Density :1.4287 (rough estimate)
refractive index :1.6590 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
pka :13.46±0.70(Predicted)
form :lyophilized powder
color :White to Off-white
Water Solubility :0.5-1.0 g/100 mL at 21 ºC
Merck :14,887
BRN :620461
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey :NMUSYJAQQFHJEW-WGDKFINWSA-N
LogP :-2.191 (est)
CAS DataBase Reference :320-67-2(CAS DataBase Reference)
IARC :2A (Vol. 50) 1990
EPA Substance Registry System :Azacitidine (320-67-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines). 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.

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