4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
![4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile price.](/CAS/GIF/500287-72-9.gif)
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- $12 - $2194.5
- Product name: 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
- CAS: 500287-72-9
- MF: C22H18N6
- MW: 366.42
- EINECS:
- MDL Number:MFCD11046372
- Synonyms:4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile;4-[[4-[[4-[(E)-2-Cyanovinyl]-2,6-diMethylphenyl]aMino]pyriMidin-2-yl]aMino]benzonitrile;4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-diMethylphenyl}aMino)pyriMidin-2-yl]aMino}benzonitrile;Rilpivirine(R 278474;Rilpivirine (R 278474, TMC 278);4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile;R 278474;TMC 278
31 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
- Usbiological
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- 10mM(in 1mL DMSO)
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 1000mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3750-M025
- Product descriptionRilpivirine ≥98%(HPLC)
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberW9902
- Product descriptionRilpivirine
- Packaging50mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging1mg
- Price$12
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging5mg
- Price$21
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging10mg
- Price$27
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging50mg
- Price$46
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging100mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging250mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA112484
- Product description(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+%
- Packaging1g
- Price$289
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008127
- Product descriptionRILPIVIRINE 95.00%
- Packaging10MG
- Price$299.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008127
- Product descriptionRILPIVIRINE 95.00%
- Packaging25MG
- Price$2194.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3765
- Product descriptionRilpivirine
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3765
- Product descriptionRilpivirine
- Packaging10mM(in 1mL DMSO)
- Price$173
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3765
- Product descriptionRilpivirine
- Packaging50mg
- Price$469
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181114
- Product descriptionRilpivirine(R 278474, TMC 278) >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181114
- Product descriptionRilpivirine(R 278474, TMC 278) >98%
- Packaging250mg
- Price$838.1
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3750-M025 | Rilpivirine ≥98%(HPLC) | 25mg | $200 | 2021-12-16 | Buy |
| AK Scientific | W9902 | Rilpivirine | 50mg | $473 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 1mg | $12 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 5mg | $21 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 10mg | $27 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 50mg | $46 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 100mg | $60 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 250mg | $116 | 2021-12-16 | Buy |
| Ambeed | A112484 | (E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 98+% | 1g | $289 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008127 | RILPIVIRINE 95.00% | 10MG | $299.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008127 | RILPIVIRINE 95.00% | 25MG | $2194.5 | 2021-12-16 | Buy |
| ApexBio Technology | A3765 | Rilpivirine | 10mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | A3765 | Rilpivirine | 10mM(in 1mL DMSO) | $173 | 2021-12-16 | Buy |
| ApexBio Technology | A3765 | Rilpivirine | 50mg | $469 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181114 | Rilpivirine(R 278474, TMC 278) >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181114 | Rilpivirine(R 278474, TMC 278) >98% | 250mg | $838.1 | 2021-12-16 | Buy |
Properties
Melting point :245℃
Boiling point :634.1±65.0 °C(Predicted)
Density :1.27
storage temp. :Refrigerator
solubility :Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
pka :4.56±0.10(Predicted)
form :Solid
color :Yellow
Boiling point :634.1±65.0 °C(Predicted)
Density :1.27
storage temp. :Refrigerator
solubility :Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
pka :4.56±0.10(Predicted)
form :Solid
color :Yellow
Safety Information
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Description
In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),～10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.Related product price
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$29-2245.7
Suppliers and manufacturers
career henan chemical co
![4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile](https://img.chemicalbook.com/ProductImageEN/2018-12/small/a8d9b725-3501-41e9-8ab0-ffa7fdbdccca.jpg)
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Shaanxi Yikanglong Biotechnology Co., Ltd.
Biochempartner
Hubei xin bonus chemical co. LTD
BOC Sciences
$2.00 /1kg
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile CAS:500287-72-9
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile CAS:500287-72-9