RNA Polymerase III Inhibitor
|
- $29 - $2400
- Product name: RNA Polymerase III Inhibitor
- CAS: 577784-91-9
- MF: C19H15Cl2N3O2S2
- MW: 452.38
- EINECS:
- MDL Number:MFCD00112663
- Synonyms:RNA Polymerase III Inhibitor;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218;RNA Polymerase III Inhibitor inhibitor;2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide
20 prices
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Brand
- aablocks
- ACHEMBLOCK
- AvaChem
- ChemScene
- DC Chemicals
- Sigma-Aldrich
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1g
- 1 unit
- 5 mg
- Manufactureraablocks
- Product numberAA00ELXS
- Product description2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide ≥97%
- Packaging1mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ELXS
- Product description2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98%
- Packaging5mg
- Price$67
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ELXS
- Product description2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98%
- Packaging10mg
- Price$86
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ELXS
- Product description2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98%
- Packaging25mg
- Price$170
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ELXS
- Product description2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98%
- Packaging50mg
- Price$287
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228204
- Product descriptionML-60218 97.00%
- Packaging100MG
- Price$650
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228204
- Product descriptionML-60218 97.00%
- Packaging25MG
- Price$200
- Updated2026-05-27
- Buy
- ManufacturerAvaChem
- Product number6549
- Product descriptionML-60218 98%
- Packaging5mg
- Price$90
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6549
- Product descriptionML-60218 98%
- Packaging25mg
- Price$360
- Updated2026-05-22
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 99.69%
- Packaging10mg
- Price$260
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 99.69%
- Packaging25mg
- Price$542
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 99.69%
- Packaging50mg
- Price$867
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 99.69%
- Packaging5mg
- Price$162
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0081935
- Product descriptionML-60218 99.69%
- Packaging100mg
- Price$1235
- Updated2026-06-04
- Buy
- ManufacturerDC Chemicals
- Product numberDC21322
- Product descriptionML-60218 98%
- Packaging1g
- Price$2400
- Updated2026-05-24
- Buy
- ManufacturerDC Chemicals
- Product numberDC21322
- Product descriptionML-60218 98%
- Packaging250mg
- Price$1200
- Updated2026-05-24
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ELXS | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide ≥97% | 1mg | $29 | 2026-05-28 | Buy |
| aablocks | AA00ELXS | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98% | 5mg | $67 | 2026-05-28 | Buy |
| aablocks | AA00ELXS | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98% | 10mg | $86 | 2026-05-28 | Buy |
| aablocks | AA00ELXS | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98% | 25mg | $170 | 2026-05-28 | Buy |
| aablocks | AA00ELXS | 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide 98% | 50mg | $287 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228204 | ML-60218 97.00% | 100MG | $650 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228204 | ML-60218 97.00% | 25MG | $200 | 2026-05-27 | Buy |
| AvaChem | 6549 | ML-60218 98% | 5mg | $90 | 2026-05-22 | Buy |
| AvaChem | 6549 | ML-60218 98% | 25mg | $360 | 2026-05-22 | Buy |
| ChemScene | CS-0081935 | ML-60218 99.69% | 10mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-0081935 | ML-60218 99.69% | 25mg | $542 | 2026-06-04 | Buy |
| ChemScene | CS-0081935 | ML-60218 99.69% | 50mg | $867 | 2026-06-04 | Buy |
| ChemScene | CS-0081935 | ML-60218 99.69% | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0081935 | ML-60218 99.69% | 100mg | $1235 | 2026-06-04 | Buy |
| DC Chemicals | DC21322 | ML-60218 98% | 1g | $2400 | 2026-05-24 | Buy |
| DC Chemicals | DC21322 | ML-60218 98% | 250mg | $1200 | 2026-05-24 | Buy |
Properties
storage temp. := -70C
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
form :Off-white solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChI :1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
InChIKey :BVBDTTLISMIOJY-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
form :Off-white solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChI :1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
InChIKey :BVBDTTLISMIOJY-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl
Safety Information
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Description
ML-60218 is a small molecule inhibitor of RNA polymerase III in both S. cerevisiae and human with IC50 values of 32 and 27 μM, respectively. At 200 μM, it has been shown to inhibit 88, 94, and 90% of the in vitro transcription activity of S. cerevisiae, C. albicans, and human RNA polmerase III, respectively. In combination with HDAC inhibition, ML-60218 at 100 μM has been used to target transcription during exocrine pancreatic epithelial proliferation in a zebrafish model of pancreatic cancer.Related product price
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Suppliers and manufacturers
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Nanjing Dulai Biotechnology Co., Ltd.
Sigma-Aldrich
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Beijing Solarbio Science & Tecnology Co., Ltd.
Shanghai Jizhi Biochemical Technology Co. Ltd.
