4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
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- $93 - $1253
- Product name: 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
- CAS: 58131-57-0
- MF: C11H13N5O4
- MW: 279.25
- EINECS:200-258-5
- MDL Number:MFCD01908645
- Synonyms:4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide;4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide;7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide;XI-006 (NSC207895)=1119;NSC-207895;NSC-207895 (XI-006);NSC 179940;4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide
8 prices
Selected condition：
Brand
- ApexBio Technology
- Cayman Chemical
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerApexBio Technology
- Product numberA4209
- Product descriptionNSC207895(XI-006)
- Packaging5mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4209
- Product descriptionNSC207895(XI-006)
- Packaging10mg
- Price$415
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4209
- Product descriptionNSC207895(XI-006)
- Packaging50mg
- Price$1253
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27949
- Product descriptionNSC 207895
- Packaging1mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27949
- Product descriptionNSC 207895
- Packaging5mg
- Price$252
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27949
- Product descriptionNSC 207895
- Packaging10mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27949
- Product descriptionNSC 207895
- Packaging25mg
- Price$911
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberN900558
- Product descriptionNSC-207895
- Packaging10mg
- Price$450
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | A4209 | NSC207895(XI-006) | 5mg | $221 | 2021-12-16 | Buy |
| ApexBio Technology | A4209 | NSC207895(XI-006) | 10mg | $415 | 2021-12-16 | Buy |
| ApexBio Technology | A4209 | NSC207895(XI-006) | 50mg | $1253 | 2021-12-16 | Buy |
| Cayman Chemical | 27949 | NSC 207895 | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 27949 | NSC 207895 | 5mg | $252 | 2024-03-01 | Buy |
| Cayman Chemical | 27949 | NSC 207895 | 10mg | $456 | 2024-03-01 | Buy |
| Cayman Chemical | 27949 | NSC 207895 | 25mg | $911 | 2024-03-01 | Buy |
| TRC | N900558 | NSC-207895 | 10mg | $450 | 2021-12-16 | Buy |
Properties
Boiling point :487.6±55.0 °C(Predicted)
Density :1.64
storage temp. :Store at -20°C
solubility :Limited solubility
form :Powder
pka :6.23±0.42(Predicted)
Density :1.64
storage temp. :Store at -20°C
solubility :Limited solubility
form :Powder
pka :6.23±0.42(Predicted)
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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Description
NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).More related product prices
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