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ChemicalBook >> CAS DataBase List >> 4-AMINO-5-CYANO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE

4-AMINO-5-CYANO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE

4-AMINO-5-CYANO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE price.
  • $25 - $450
  • Product name: 4-AMINO-5-CYANO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE
  • CAS: 606-58-6
  • MF: C12H13N5O4
  • MW: 291.26
  • EINECS:
  • MDL Number:MFCD00866513
  • Synonyms:NSC 63701;NSC 99843;TOYOCAMYCIN;3-d)pyrimidine-5-carbonitrile,4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo( ;4-amino-5-cyano-7-(d-ribofuranosyl)-7h-pyrrolo(2,3-d)pyrimidine ;4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d)pyrimidine-5-carbonitrile ;a-399-y4 ;ahygroscopin-b
24 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 10MG
  • 50
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0015849
  • Product description4-AMINO-7-BETA-D-RIBOFURANOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE 95.00%
  • Packaging10MG
  • Price$197.4
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7795
  • Product descriptionToyocamycin
  • Packaging50mg
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNT44985
  • Product descriptionToyocamycin
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNT44985
  • Product descriptionToyocamycin
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNT44985
  • Product descriptionToyocamycin
  • Packaging25mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNT44985
  • Product descriptionToyocamycin
  • Packaging50mg
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNT44985
  • Product descriptionToyocamycin
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17371
  • Product descriptionToyocamycin ≥98%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17371
  • Product descriptionToyocamycin ≥98%
  • Packaging5mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17371
  • Product descriptionToyocamycin ≥98%
  • Packaging10mg
  • Price$63
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17371
  • Product descriptionToyocamycin ≥98%
  • Packaging25mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0026179
  • Product descriptionToyocamycin >99.0%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0026179
  • Product descriptionToyocamycin >99.0%
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0026179
  • Product descriptionToyocamycin >99.0%
  • Packaging50mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0026179
  • Product descriptionToyocamycin >99.0%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD70000821
  • Product description4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 97%
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0015849 4-AMINO-7-BETA-D-RIBOFURANOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE 95.00% 10MG $197.4 2021-12-16 Buy
ApexBio Technology B7795 Toyocamycin 50mg $410 2021-12-16 Buy
Biosynth Carbosynth NT44985 Toyocamycin 5mg $60 2021-12-16 Buy
Biosynth Carbosynth NT44985 Toyocamycin 10mg $95 2021-12-16 Buy
Biosynth Carbosynth NT44985 Toyocamycin 25mg $175 2021-12-16 Buy
Biosynth Carbosynth NT44985 Toyocamycin 50mg $275 2021-12-16 Buy
Biosynth Carbosynth NT44985 Toyocamycin 100mg $450 2021-12-16 Buy
Cayman Chemical 17371 Toyocamycin ≥98% 1mg $25 2021-12-16 Buy
Cayman Chemical 17371 Toyocamycin ≥98% 5mg $56 2021-12-16 Buy
Cayman Chemical 17371 Toyocamycin ≥98% 10mg $63 2021-12-16 Buy
Cayman Chemical 17371 Toyocamycin ≥98% 25mg $125 2021-12-16 Buy
ChemScene CS-0026179 Toyocamycin >99.0% 5mg $50 2021-12-16 Buy
ChemScene CS-0026179 Toyocamycin >99.0% 10mg $75 2021-12-16 Buy
ChemScene CS-0026179 Toyocamycin >99.0% 50mg $260 2021-12-16 Buy
ChemScene CS-0026179 Toyocamycin >99.0% 100mg $450 2021-12-16 Buy
Crysdot CD70000821 4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 97% 10mg $170 2021-12-16 Buy

Properties

Melting point :243°; mp 239-243°
alpha :D16 -45.7° (c = 1.05 in 0.1N HCl)
Boiling point :433.28°C (rough estimate)
Density :1.3067 (rough estimate)
refractive index :1.7000 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble0.90 - 1.10mg/mL, clear, colorless
form :solid
pka :12.31±0.70(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Toyocamycin is a natural adenosine analog first isolated from Streptomyces and shown in early studies to be cytotoxic to bacteria, fungi, and cancer cells and to have antiviral activities. Toyocamycin prevents IRE1α-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple myeloma cell lines. It is used to study IRE1α action in the endoplasmic reticulum stress response, particularly in the context of cancer. It also inhibits phosphatidylinositol kinase in vitro (IC50 = 3.3 μg/ml), but not in cells, and blocks the ribosomal RNA-processing kinase Rio1 (IC50 = ~30 nM).

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