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ChemicalBook >> CAS DataBase List >> 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile price.
  • $57 - $1600
  • Product name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • CAS: 871307-18-5
  • MF: C21H14ClFN6
  • MW: 404.83
  • EINECS:
  • MDL Number:
  • Synonyms:4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile;Tpl2 Kinase Inhibitor;4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile;Tpl2-IN-2p;TC-S 7006;1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-;Tpl2 Kinase Inhibitor 1;Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1
Price21 Properties Safety Information Description
21 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 2mg
  • 10
  • 1mg
  • 50
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 1g
  • 1 mg
  • ManufacturerAK Scientific
  • Product number9767CQ
  • Product descriptionTpl2KinaseInhibitor
  • Packaging1mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number871307185
  • Product description4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile
  • Packaging1g
  • Price$960
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000897
  • Product description4-(3-CHLORO-4-FLUOROPHENYLAMINO)-6-(PYRIDIN-3-YL-METHYLAMINO)-3-CYANO-[1,7]-NAPHTHYRIDINE 95.00%
  • Packaging5MG
  • Price$504.59
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging2mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging5mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging10mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging25mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging50mg
  • Price$1600
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging5mg
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging10mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging25mg
  • Price$684
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0011091
  • Product descriptionTpl2KinaseInhibitor1 ≥99.0%
  • Packaging5mg
  • Price$515
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11039730
  • Product description4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+%
  • Packaging5mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11039730
  • Product description4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+%
  • Packaging10mg
  • Price$1360
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number616373
  • Product descriptionTpl2 Kinase Inhibitor The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor
  • Packaging1 mg
  • Price$238
  • Updated2026-03-19
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9767CQ Tpl2KinaseInhibitor 1mg $156 2021-12-16 Buy
Alichem 871307185 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 1g $960 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000897 4-(3-CHLORO-4-FLUOROPHENYLAMINO)-6-(PYRIDIN-3-YL-METHYLAMINO)-3-CYANO-[1,7]-NAPHTHYRIDINE 95.00% 5MG $504.59 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 2mg $160 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 5mg $300 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 10mg $500 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 25mg $1000 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 50mg $1600 2021-12-16 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 5mg $220 2024-03-01 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 10mg $302 2024-03-01 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 25mg $684 2024-03-01 Buy
ChemScene CS-0011091 Tpl2KinaseInhibitor1 ≥99.0% 5mg $515 2021-12-16 Buy
Crysdot CD11039730 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+% 5mg $720 2021-12-16 Buy
Crysdot CD11039730 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+% 10mg $1360 2021-12-16 Buy
Sigma-Aldrich 616373 Tpl2 Kinase Inhibitor The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor 1 mg $238 2026-03-19 Buy
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Properties

Boiling point :616.3±55.0 °C(Predicted)
Density :1.45
storage temp. :2-8°C
solubility :DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml
form :A crystalline solid
pka :4.80±0.10(Predicted)
color :Yellow to green
InChI :1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
InChIKey :NMEUKWOOQOHUNA-UHFFFAOYSA-N
SMILES :Fc1c(cc(cc1)Nc2c3c(ncc2C#N)cnc(c3)NCc4cnccc4)Cl

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50 = 0.05 μM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D3 (calcitriol; ) in HL-60 and U937 leukemia cells when used at a concentration of 5 μM. Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.

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TargetMol Chemicals Inc.
Tpl2 Kinase Inhibitor 1
$198.00 /1mg
Tpl2 Kinase Inhibitor 1 CAS:871307-18-5
CONIER CHEM AND PHARMA LIMITED
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SHANGHAI KEAN TECHNOLOGY CO., LTD. Shanghai EFE Biological Technology Co., Ltd. Aikon International Limited Shanghai Hongye Biotechnology Co. Ltd