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ChemicalBook >> CAS DataBase List >> 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride price.
  • $43 - $2000
  • Product name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
  • CAS: 91940-87-3
  • MF: C26H37ClN2O5
  • MW: 493.04
  • EINECS:
  • MDL Number:MFCD06798356
  • Synonyms:UL-FS49;ZATEBRADINE HYDROCHLORIDE;UL-FS49, 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride;2H-3-Benzazepin-2-one, 3-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride;Zatebradine HCl;ULFS 49CL;Zatebradine dihydrochloride;7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
Price40 Properties Safety Information Description
40 prices
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  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
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  • Manufactureraablocks
  • Product numberAA006JAS
  • Product description3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥97%
  • Packaging5mg
  • Price$114
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006JAS
  • Product description3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥95%
  • Packaging10mg
  • Price$196
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006JAS
  • Product description3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥97%
  • Packaging25mg
  • Price$412
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006JAS
  • Product description3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride 99%
  • Packaging50mg
  • Price$659
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006JAS
  • Product description3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥97%
  • Packaging100mg
  • Price$1191
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberY226442
  • Product descriptionZatebradine hydrochloride 97.00%
  • Packaging100MG
  • Price$545
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberY226442
  • Product descriptionZatebradine hydrochloride 97.00%
  • Packaging25MG
  • Price$185
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number4166AH
  • Product descriptionZatebradine hydrochloride
  • Packaging5mg
  • Price$214
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB6974
  • Product descriptionZatebradine hydrochloride
  • Packaging10mg
  • Price$154
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberB6974
  • Product descriptionZatebradine hydrochloride
  • Packaging5mg
  • Price$119
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberB6974
  • Product descriptionZatebradine hydrochloride
  • Packaging50mg
  • Price$687
  • Updated2026-05-06
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1248
  • Product descriptionZatebradine hydrochloride
  • Packaging50mg
  • Price$495
  • Updated2026-05-19
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  • ManufacturerAxon Medchem
  • Product numberAxon1248
  • Product descriptionZatebradine hydrochloride
  • Packaging10mg
  • Price$132
  • Updated2026-05-19
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  • ManufacturerBiosynth
  • Product numberRDA94087
  • Product descriptionZatebradine hydrochloride
  • Packaging25mg
  • Price$853.75
  • Updated2026-06-05
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  • ManufacturerBiosynth
  • Product numberRDA94087
  • Product descriptionZatebradine hydrochloride
  • Packaging50mg
  • Price$1365.5
  • Updated2026-06-05
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  • ManufacturerBiosynth
  • Product numberRDA94087
  • Product descriptionZatebradine hydrochloride
  • Packaging100mg
  • Price$1899
  • Updated2026-06-05
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA006JAS 3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥97% 5mg $114 2026-05-28 Buy
aablocks AA006JAS 3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥95% 10mg $196 2026-05-28 Buy
aablocks AA006JAS 3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥97% 25mg $412 2026-05-28 Buy
aablocks AA006JAS 3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride 99% 50mg $659 2026-05-28 Buy
aablocks AA006JAS 3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride ≥97% 100mg $1191 2026-05-28 Buy
ACHEMBLOCK Y226442 Zatebradine hydrochloride 97.00% 100MG $545 2026-05-27 Buy
ACHEMBLOCK Y226442 Zatebradine hydrochloride 97.00% 25MG $185 2026-05-27 Buy
AK Scientific 4166AH Zatebradine hydrochloride 5mg $214 2021-12-16 Buy
ApexBio Technology B6974 Zatebradine hydrochloride 10mg $154 2026-05-06 Buy
ApexBio Technology B6974 Zatebradine hydrochloride 5mg $119 2026-05-06 Buy
ApexBio Technology B6974 Zatebradine hydrochloride 50mg $687 2026-05-06 Buy
Axon Medchem Axon1248 Zatebradine hydrochloride 50mg $495 2026-05-19 Buy
Axon Medchem Axon1248 Zatebradine hydrochloride 10mg $132 2026-05-19 Buy
Biosynth RDA94087 Zatebradine hydrochloride 25mg $853.75 2026-06-05 Buy
Biosynth RDA94087 Zatebradine hydrochloride 50mg $1365.5 2026-06-05 Buy
Biosynth RDA94087 Zatebradine hydrochloride 100mg $1899 2026-06-05 Buy
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Properties

Melting point :188° and mp 168°
storage temp. :2-8°C
solubility :H2O: ~14 mg/mL
form :solid
color :white
Water Solubility :Soluble in water (100mM)
InChI :1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
InChIKey :ZRNKXJHEQKMWCH-UHFFFAOYSA-N
SMILES :Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Zatebradine is a bradycardic compound that blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells (IC50s = 1.83, 2.21, 1.9, and 1.88 μM, respectively for HCN1-4 in vitro). Additionally, it can block voltage-gated outward K+ (IK) currents and related neuronal hyperpolarization-activated inward current (Ih) channels, but exhibits little or no activity for L-type Ca2+ (ICa) currents. When assessed through telemetric ECG recording in mice, zatebradine reduced heart rate from 600 to 200 beats per minute with an ED50 value of 1.8 mg/kg and induced increasing arrhythmia at concentrations >10 mg/kg.

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Suppliers and manufacturers

3B Pharmachem (Wuhan) International Co.,Ltd. Haoyuan Chemexpress Co., Ltd. MedChemexpress LLC ShangHai KenEn Chemical Technology Co., Ltd. Sigma-Aldrich EMMX Biotechnology LLC Shanghai EFE Biological Technology Co., Ltd. Guangzhou QiYun Biotechnology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd.