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ChemicalBook >> CAS DataBase List >> A-1210477

A-1210477

A-1210477 price.
  • $31 - $2400
  • Product name: A-1210477
  • CAS: 1668553-26-1
  • MF: C46H55N7O7S
  • MW: 850.04
  • EINECS:
  • MDL Number:MFCD28399118
  • Synonyms:A-1210477;Abbvie Mcl-1 Inhibitor;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid;7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;CS-2202;CS-2151;A-1210477;A 1210477;A1210477;1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-
20 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Tocris
  • TRC
Package
  • 5mg
  • 25
  • 1mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9707DS
  • Product description7-[5-[[4-[4-(Dimethylsulfamoyl)piperazin-1-yl]phenoxy]methyl]-1,3-dimethylpyrazol-4-yl]-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylicacid
  • Packaging25mg
  • Price$707
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA116740
  • Product descriptionA-1210477 98+%
  • Packaging1mg
  • Price$31
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116740
  • Product descriptionA-1210477 98+%
  • Packaging5mg
  • Price$62
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116740
  • Product descriptionA-1210477 98+%
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116740
  • Product descriptionA-1210477 98+%
  • Packaging25mg
  • Price$231
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116740
  • Product descriptionA-1210477 98+%
  • Packaging50mg
  • Price$437
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA116740
  • Product descriptionA-1210477 98+%
  • Packaging100mg
  • Price$688
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004693
  • Product descriptionA-1210477 95.00%
  • Packaging5MG
  • Price$502.08
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB6011
  • Product descriptionA-1210477
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB6011
  • Product descriptionA-1210477
  • Packaging25mg
  • Price$315
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number21113
  • Product descriptionA-1210477 ≥98%
  • Packaging1mg
  • Price$38
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number21113
  • Product descriptionA-1210477 ≥98%
  • Packaging5mg
  • Price$166
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number21113
  • Product descriptionA-1210477 ≥98%
  • Packaging10mg
  • Price$292
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number21113
  • Product descriptionA-1210477 ≥98%
  • Packaging25mg
  • Price$547
  • Updated2024-03-01
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  • ManufacturerCrysdot
  • Product numberCD31003056
  • Product descriptionA-1210477 98+%
  • Packaging25mg
  • Price$224
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003056
  • Product descriptionA-1210477 98+%
  • Packaging50mg
  • Price$425
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9707DS 7-[5-[[4-[4-(Dimethylsulfamoyl)piperazin-1-yl]phenoxy]methyl]-1,3-dimethylpyrazol-4-yl]-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylicacid 25mg $707 2021-12-16 Buy
Ambeed A116740 A-1210477 98+% 1mg $31 2021-12-16 Buy
Ambeed A116740 A-1210477 98+% 5mg $62 2021-12-16 Buy
Ambeed A116740 A-1210477 98+% 10mg $110 2021-12-16 Buy
Ambeed A116740 A-1210477 98+% 25mg $231 2021-12-16 Buy
Ambeed A116740 A-1210477 98+% 50mg $437 2021-12-16 Buy
Ambeed A116740 A-1210477 98+% 100mg $688 2021-12-16 Buy
American Custom Chemicals Corporation INB0004693 A-1210477 95.00% 5MG $502.08 2021-12-16 Buy
ApexBio Technology B6011 A-1210477 5mg $105 2021-12-16 Buy
ApexBio Technology B6011 A-1210477 25mg $315 2021-12-16 Buy
Cayman Chemical 21113 A-1210477 ≥98% 1mg $38 2024-03-01 Buy
Cayman Chemical 21113 A-1210477 ≥98% 5mg $166 2024-03-01 Buy
Cayman Chemical 21113 A-1210477 ≥98% 10mg $292 2024-03-01 Buy
Cayman Chemical 21113 A-1210477 ≥98% 25mg $547 2024-03-01 Buy
Crysdot CD31003056 A-1210477 98+% 25mg $224 2021-12-16 Buy
Crysdot CD31003056 A-1210477 98+% 50mg $425 2021-12-16 Buy

Properties

Boiling point :1027.4±65.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form :Powder
pka :4.43±0.30(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 μM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1). It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.