A-1331852
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- $67 - $3772
- Product name: A-1331852
- CAS: 1430844-80-6
- MF: C38H38N6O3S
- MW: 658.81
- EINECS:
- MDL Number:MFCD30532662
- Synonyms:A-1331852;6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-(adamantylmethyl)-5-methyl-1H-pyrazol-4-yl)picolinic acid;CS-2498;A 1331852;A1331852;6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-;3-(1-(Adamantan-1-ylmethyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid;A-1331852,Inhibitor,inhibit,A1331852,Bcl-2 Family,A 1331852
54 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10.00mg
- 25.00mg
- 50.00mg
- 250mg
- 10mM(1mLinDMSO)
- 5MG
- 25MG
- 100MG
- 1G
- 10mg
- 50mg
- 10mM*1mLinDMSO(Solid+Solvent)
- ManufacturerACHEMBLOCK
- Product numberM22556
- Product descriptionA-1331852 98%
- Packaging5MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22556
- Product descriptionA-1331852 98%
- Packaging25MG
- Price$260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22556
- Product descriptionA-1331852 98%
- Packaging100MG
- Price$750
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22556
- Product descriptionA-1331852 98%
- Packaging1G
- Price$1950
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number9370DU
- Product description3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylicacid
- Packaging10mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging50mg
- Price$528
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging10mg
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging25mg
- Price$337
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging5mg
- Price$99
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging10mg
- Price$165
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging5mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging100mg
- Price$2100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging50mg
- Price$1185
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging100mg
- Price$858
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6164
- Product descriptionA-1331852
- Packaging25mg
- Price$660
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-19741
- Product descriptionA-1331852 99.93%
- Packaging50mg
- Price$665
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | M22556 | A-1331852 98% | 5MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22556 | A-1331852 98% | 25MG | $260 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22556 | A-1331852 98% | 100MG | $750 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22556 | A-1331852 98% | 1G | $1950 | 2026-05-27 | Buy |
| AK Scientific | 9370DU | 3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylicacid | 10mg | $473 | 2021-12-16 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 50mg | $528 | 2026-05-06 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 10mg | $315 | 2021-12-16 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 25mg | $337 | 2026-05-06 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 5mg | $99 | 2026-05-06 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 10mg | $165 | 2026-05-06 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 5mg | $195 | 2021-12-16 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 100mg | $2100 | 2021-12-16 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 50mg | $1185 | 2021-12-16 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 100mg | $858 | 2026-05-06 | Buy |
| ApexBio Technology | B6164 | A-1331852 | 25mg | $660 | 2021-12-16 | Buy |
| Arctom | HY-19741 | A-1331852 99.93% | 50mg | $665 | 2026-05-26 | Buy |
Properties
Melting point :>161oC (dec.)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Acetonitrile (Slightly, Heated), DMSO (Slightly)
pka :8.88±0.70(Predicted)
form :Solid
color :Pale Yellow to Light Beige
InChIKey :QCQQONWEDCOTBV-UHFFFAOYSA-N
SMILES :C1(C(O)=O)=NC(N2CCC3=C(C2)C(C(NC2=NC4=CC=CC=C4S2)=O)=CC=C3)=CC=C1C1=C(C)N(CC23CC4CC(CC(C4)C2)C3)N=C1
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Acetonitrile (Slightly, Heated), DMSO (Slightly)
pka :8.88±0.70(Predicted)
form :Solid
color :Pale Yellow to Light Beige
InChIKey :QCQQONWEDCOTBV-UHFFFAOYSA-N
SMILES :C1(C(O)=O)=NC(N2CCC3=C(C2)C(C(NC2=NC4=CC=CC=C4S2)=O)=CC=C3)=CC=C1C1=C(C)N(CC23CC4CC(CC(C4)C2)C3)N=C1
Safety Information
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Description
A-1331852 is an orally bioavailable Bcl-xL inhibitor that selectively binds Bcl-xL over Bcl-2, Mcl-1, and Bcl-W (Kis = <0.01, 6, 142, and 4 nM, respectively). It inhibits growth of Bcl-xL-dependent MOLT-4, but not Bcl-2-dependent RS4;11, acute lymphocytic leukemia cells in vitro (EC50s = 6 and >5,000 nM, respectively). A-1331852 (25 mg/kg twice per day) inhibits tumor growth in a MOLT-4 mouse xenograft model. It also inhibits tumor growth and increases the antitumor activity of docetaxel in MDA-MB-231 LC3 metastatic breast cancer and NCI-H1650 non-small cell lung cancer mouse xenograft models when administered at a dose of 25 mg/kg. A-1331852 also increases venetoclax inhibition of tumor growth in an NCI-H1963.FP5 small cell lung cancer mouse xenograft model.More related product prices
5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL ascochlorin